Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1994 Mar;38(3):602–603. doi: 10.1128/aac.38.3.602

Effects of broad-spectrum antibiotics on colonization of gastrointestinal tracts of mice by Candida albicans.

G Samonis 1, H Anastassiadou 1, M Dassiou 1, Y Tselentis 1, G P Bodey 1
PMCID: PMC284504  PMID: 8203861

Abstract

Three-month-old, male, Crl:CD1 (ICR) BR mice were fed chow containing Candida albicans or regular chow. Subsequently, both groups were given either antibiotics or normal saline for 10 days. Stool cultures were performed immediately before administration, at the end of antibiotic administration, and 1 week after the discontinuation of antibiotics, to determine the effect on the concentration of C. albicans in the stools. The stools of mice fed C. albicans and given antibiotics had substantially higher Candida counts than those of control mice fed C. albicans and given saline. Significantly higher candidal concentrations were observed in the stools of mice given chloramphenicol compared with those of mice given ciprofloxacin, sulfamethoxazole-trimethoprim, and ampicillin. No mice developed histopathological evidence of local gastrointestinal invasion or disseminated candidiasis. In this mouse model, Candida colonization increases substantially after the administration of antimicrobial agents with broad spectra and anaerobic activities.

Full text

PDF
602

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartoloni A., Fanci R., Orsi A., Aquilini D., Bosi A., Rossi Ferrini P., Paradisi F. The influence of ofloxacin versus trimethoprim-sulfamethoxazole on the aerobic flora in granulocytopenic subjects. J Chemother. 1989 Apr;1(2):91–94. doi: 10.1080/1120009x.1989.11738871. [DOI] [PubMed] [Google Scholar]
  2. Black F., Einarsson K., Lidbeck A., Orrhage K., Nord C. E. Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scand J Infect Dis. 1991;23(2):247–254. doi: 10.3109/00365549109023408. [DOI] [PubMed] [Google Scholar]
  3. Bodey G. P. Candidiasis in cancer patients. Am J Med. 1984 Oct 30;77(4D):13–19. [PubMed] [Google Scholar]
  4. Bridges C. G., Dasilva G. L., Yamamura M., Valdimarsson H. A radiometric assay for the combined measurement of phagocytosis and intracellular killing of Candida albicans. Clin Exp Immunol. 1980 Nov;42(2):226–233. [PMC free article] [PubMed] [Google Scholar]
  5. Domer J. E., Hector R. F. Enhanced immune responses in mice treated with penicillin-tetracycline or trimethoprim-sulfamethoxazole when colonized intragastrically with Candida albicans. Antimicrob Agents Chemother. 1987 May;31(5):691–697. doi: 10.1128/aac.31.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Edlund C., Nord C. E. A review on the impact of 4-quinolones on the normal oropharyngeal and intestinal human microflora. Infection. 1988;16(1):8–12. doi: 10.1007/BF01646921. [DOI] [PubMed] [Google Scholar]
  7. Fass R. J. Efficacy and safety of oral ciprofloxacin for treatment of serious urinary tract infections. Antimicrob Agents Chemother. 1987 Feb;31(2):148–150. doi: 10.1128/aac.31.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Freireich E. J., Gehan E. A., Rall D. P., Schmidt L. H., Skipper H. E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep. 1966 May;50(4):219–244. [PubMed] [Google Scholar]
  9. Kennedy M. J., Volz P. A. Effect of various antibiotics on gastrointestinal colonization and dissemination by Candida albicans. Sabouraudia. 1985 Aug;23(4):265–273. doi: 10.1080/00362178585380391. [DOI] [PubMed] [Google Scholar]
  10. Musial C. E., Cockerill F. R., 3rd, Roberts G. D. Fungal infections of the immunocompromised host: clinical and laboratory aspects. Clin Microbiol Rev. 1988 Oct;1(4):349–364. doi: 10.1128/cmr.1.4.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Samonis G., Anaissie E. J., Bodey G. P. Effects of broad-spectrum antimicrobial agents on yeast colonization of the gastrointestinal tracts of mice. Antimicrob Agents Chemother. 1990 Dec;34(12):2420–2422. doi: 10.1128/aac.34.12.2420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Samonis G., Anaissie E. J., Rosenbaum B., Bodey G. P. A model of sustained gastrointestinal colonization by Candida albicans in healthy adult mice. Infect Immun. 1990 Jun;58(6):1514–1517. doi: 10.1128/iai.58.6.1514-1517.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scully B. E., Jules K., Chin N. X., Neu H. C. Effect of ciprofloxacin on fecal flora of patients with cystic fibrosis and other patients treated with oral ciprofloxacin. Am J Med. 1987 Apr 27;82(4A):336–338. [PubMed] [Google Scholar]
  14. Sjövall J., Huitfeldt B., Magni L., Nord C. E. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73–84. [PubMed] [Google Scholar]
  15. Vlaspolder F., de Zeeuw G., Rozenberg-Arska M., Egyedi P., Verhoef J. The influence of flucloxacillin and amoxicillin with clavulanic acid on the aerobic flora of the alimentary tract. Infection. 1987 Jul-Aug;15(4):241–244. doi: 10.1007/BF01644122. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES