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. 1994 Mar;38(3):616–619. doi: 10.1128/aac.38.3.616

Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model.

L D Condreay 1, R W Jansen 1, T F Powdrill 1, L C Johnson 1, D W Selleseth 1, M T Paff 1, S M Daluge 1, G R Painter 1, P A Furman 1, M N Ellis 1, et al.
PMCID: PMC284508  PMID: 7515609

Abstract

A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (FTC). No effects on tumor size or alpha-fetoprotein levels were observed. FTC can selectively inhibit HBV replication at nontoxic doses.

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Selected References

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