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. 1994 Mar;38(3):632–634. doi: 10.1128/aac.38.3.632

Determination of pefloxacin concentration in mesenteric lymph nodes by high-performance chromatography.

M I Munera 1, F Cuesta 1, A Abadia 1, J Vasquez 1, M Restrepo 1
PMCID: PMC284512  PMID: 8203867

Abstract

Ten patients who had undergone laparotomies for different abdominal pathological conditions were studied to determine the levels of pefloxacin in mesenteric lymph nodes. Each patient was given 400 mg of oral pefloxacin every 12 h for the 3 days prior to surgery. Drug levels in tissue were determined by high-pressure liquid chromatography (reverse phase); the mean +/- standard deviation was 17.1 +/- 11.9 micrograms/g, with a range of 2.12 to 36.6 micrograms/g. This indicates an adequate pefloxacin concentration in lymph nodes and makes the drug a good option for the treatment of conditions in which lymph nodes act as an infection-promoting and/or relapse-favoring factor.

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Selected References

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  1. Brion N., Lessana A., Mosset F., Lefevre J. J., Montay G. Penetration of pefloxacin in human heart valves. J Antimicrob Chemother. 1986 Apr;17 (Suppl B):89–92. doi: 10.1093/jac/17.suppl_b.89. [DOI] [PubMed] [Google Scholar]
  2. Dellamonica P., Bernard E., Etesse H., Garraffo R. The diffusion of pefloxacin into bone and the treatment of osteomyelitis. J Antimicrob Chemother. 1986 Apr;17 (Suppl B):93–102. doi: 10.1093/jac/17.suppl_b.93. [DOI] [PubMed] [Google Scholar]
  3. Gehanno P., Depondt J., Véber F., Guédon C., Moisy N. L'infection postopératoire en chirurgie carcinologique ORL. Le choix de l'antibiothérapie prophylactique. L'expérience du Service ORL de l'Hôpital Claude Bernard. Ann Otolaryngol Chir Cervicofac. 1985;102(3):187–193. [PubMed] [Google Scholar]
  4. Gerding D. N., Hitt J. A. Tissue penetration of the new quinolones in humans. Rev Infect Dis. 1989 Jul-Aug;11 (Suppl 5):S1046–S1057. doi: 10.1093/clinids/11.supplement_5.s1046. [DOI] [PubMed] [Google Scholar]
  5. Hand W. L., Corwin R. W., Steinberg T. H., Grossman G. D. Uptake of antibiotics by human alveolar macrophages. Am Rev Respir Dis. 1984 Jun;129(6):933–937. doi: 10.1164/arrd.1984.129.6.933. [DOI] [PubMed] [Google Scholar]
  6. Montay G., Goueffon Y., Roquet F. Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans. Antimicrob Agents Chemother. 1984 Apr;25(4):463–472. doi: 10.1128/aac.25.4.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Montay G., Tassel J. P. Improved high-performance liquid chromatographic determination of pefloxacin and its metabolite norfloxacin in human plasma and tissue. J Chromatogr. 1985 Apr 12;339(1):214–218. doi: 10.1016/s0378-4347(00)84647-2. [DOI] [PubMed] [Google Scholar]
  8. Pocidalo J. J. Use of fluoroquinolones for intracellular pathogens. Rev Infect Dis. 1989 Jul-Aug;11 (Suppl 5):S979–S984. doi: 10.1093/clinids/11.supplement_5.s979. [DOI] [PubMed] [Google Scholar]
  9. Wolfson J. S., Hooper D. C. Pharmacokinetics of quinolones: newer aspects. Eur J Clin Microbiol Infect Dis. 1991 Apr;10(4):267–274. doi: 10.1007/BF01967000. [DOI] [PubMed] [Google Scholar]
  10. Zavala Trujillo I., Quiroz C., Gutierrez M. A., Arias J., Renteria M. Fluoroquinolones in the treatment of typhoid fever and the carrier state. Eur J Clin Microbiol Infect Dis. 1991 Apr;10(4):334–341. doi: 10.1007/BF01967008. [DOI] [PubMed] [Google Scholar]

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