Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1994 Apr;38(4):787–789. doi: 10.1128/aac.38.4.787

Pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques.

C M Pereira 1, C Nosbisch 1, J D Unadkat 1
PMCID: PMC284543  PMID: 8031047

Abstract

To determine whether age affects the pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques (Macaca nemestrina), dideoxyinosine (10 mg/kg of body weight) was administered as a single intravenous bolus to macaques at ages < 1 week, 1 month, and 4 months. Clearance from plasma at < 1 week of age was significantly lower (P < 0.05) and the terminal half-life was significantly higher than the corresponding values obtained at 1 month and 4 months of age. Our data indicate that the pharmacokinetics of dideoxyinosine change significantly with age in M. nemestrina.

Full text

PDF
787

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arant B. S., Jr Developmental patterns of renal functional maturation compared in the human neonate. J Pediatr. 1978 May;92(5):705–712. doi: 10.1016/s0022-3476(78)80133-4. [DOI] [PubMed] [Google Scholar]
  2. Balis F. M., Pizzo P. A., Butler K. M., Hawkins M. E., Brouwers P., Husson R. N., Jacobsen F., Blaney S. M., Gress J., Jarosinski P. Clinical pharmacology of 2',3'-dideoxyinosine in human immunodeficiency virus-infected children. J Infect Dis. 1992 Jan;165(1):99–104. doi: 10.1093/infdis/165.1.99. [DOI] [PubMed] [Google Scholar]
  3. Boucher F. D., Modlin J. F., Weller S., Ruff A., Mirochnick M., Pelton S., Wilfert C., McKinney R., Jr, Crain M. J., Elkins M. M. Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus. J Pediatr. 1993 Jan;122(1):137–144. doi: 10.1016/s0022-3476(05)83507-3. [DOI] [PubMed] [Google Scholar]
  4. Drusano G. L., Yuen G. J., Lambert J. S., Seidlin M., Dolin R., Valentine F. T. Relationship between dideoxyinosine exposure, CD4 counts, and p24 antigen levels in human immunodeficiency virus infection. A phase I trial. Ann Intern Med. 1992 Apr 1;116(7):562–566. doi: 10.7326/0003-4819-116-7-562. [DOI] [PubMed] [Google Scholar]
  5. Drusano G. L., Yuen G. J., Morse G., Cooley T. P., Seidlin M., Lambert J. S., Liebman H. A., Valentine F. T., Dolin R. Impact of bioavailability on determination of the maximal tolerated dose of 2',3'-dideoxyinosine in phase I trials. Antimicrob Agents Chemother. 1992 Jun;36(6):1280–1283. doi: 10.1128/aac.36.6.1280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hartman N. R., Yarchoan R., Pluda J. M., Thomas R. V., Marczyk K. S., Broder S., Johns D. G. Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection. Clin Pharmacol Ther. 1990 May;47(5):647–654. doi: 10.1038/clpt.1990.86. [DOI] [PubMed] [Google Scholar]
  7. Husson R. N., Chung Y., Mordenti J., Butler K. M., Chen S., Duliege A. M., Brouwers P., Jarosinski P., Mueller B. U., Ammann A. Phase I study of continuous-infusion soluble CD4 as a single agent and in combination with oral dideoxyinosine therapy in children with symptomatic human immunodeficiency virus infection. J Pediatr. 1992 Oct;121(4):627–633. doi: 10.1016/s0022-3476(05)81161-8. [DOI] [PubMed] [Google Scholar]
  8. Knupp C. A., Shyu W. C., Dolin R., Valentine F. T., McLaren C., Martin R. R., Pittman K. A., Barbhaiya R. H. Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex. Clin Pharmacol Ther. 1991 May;49(5):523–535. doi: 10.1038/clpt.1991.63. [DOI] [PubMed] [Google Scholar]
  9. Leake R. D., Trygstad C. W. Glomerular filtration rate during the period of adaptation to extrauterine life. Pediatr Res. 1977 Sep;11(9 Pt 1):959–962. doi: 10.1203/00006450-197709000-00005. [DOI] [PubMed] [Google Scholar]
  10. Lopez-Anaya A., Unadkat J. D., Calkins D. F., Smith A. L. Effect of age on distribution of zidovudine (azidothymidine) into the cerebrospinal fluid of Macaca nemestrina. Pharm Res. 1993 Sep;10(9):1338–1340. doi: 10.1023/a:1018977915364. [DOI] [PubMed] [Google Scholar]
  11. Lopez-Anaya A., Unadkat J. D., Schumann L. A., Smith A. L. Pharmacokinetics of zidovudine (azidothymidine). I. Transplacental transfer. J Acquir Immune Defic Syndr. 1990;3(10):959–964. [PubMed] [Google Scholar]
  12. Lopez-Anaya A., Unadkat J. D., Schumann L. A., Smith A. L. Pharmacokinetics of zidovudine (azidothymidine). II. Development of metabolic and renal clearance pathways in the neonate. J Acquir Immune Defic Syndr. 1990;3(11):1052–1058. [PubMed] [Google Scholar]
  13. Pereira C. M., Nosbisch C., Winter H. R., Baughman W. L., Unadkat J. D. Transplacental pharmacokinetics of dideoxyinosine in pigtailed macaques. Antimicrob Agents Chemother. 1994 Apr;38(4):781–786. doi: 10.1128/aac.38.4.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pizzo P. A. Considerations for the evaluation of antiretroviral agents in infants and children infected with human immunodeficiency virus: a perspective from the National Cancer Institute. Rev Infect Dis. 1990 Jul-Aug;12 (Suppl 5):S561–S569. doi: 10.1093/clinids/12.supplement_5.s561. [DOI] [PubMed] [Google Scholar]
  15. Ravasco R. J., Unadkat J. D., Tsai C. C., Nosbisch C. Pharmacokinetics of dideoxyinosine in pigtailed macaques (Macaca nemestrina) after intravenous and subcutaneous administration. J Acquir Immune Defic Syndr. 1992 Oct;5(10):1016–1018. [PubMed] [Google Scholar]
  16. Shelton M. J., O'Donnell A. M., Morse G. D. Didanosine. Ann Pharmacother. 1992 May;26(5):660–670. doi: 10.1177/106002809202600511. [DOI] [PubMed] [Google Scholar]
  17. Yarchoan R., Mitsuya H., Thomas R. V., Pluda J. M., Hartman N. R., Perno C. F., Marczyk K. S., Allain J. P., Johns D. G., Broder S. In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine. Science. 1989 Jul 28;245(4916):412–415. doi: 10.1126/science.2502840. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES