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. 1994 Apr;38(4):857–860. doi: 10.1128/aac.38.4.857

Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump.

G G Guay 1, M Tuckman 1, D M Rothstein 1
PMCID: PMC284555  PMID: 8031059

Abstract

The tetA(B) gene from transposon Tn10 fails to mediate resistance to the novel tetracycline analog 9-(dimethylglycylamido)minocycline (DMG-Mino) (P. E. Sum, V. J. Lee, R. T. Testa, J. J. Hlavka, G. A. Ellestad, J. D. Bloom, Y. Gluzman, and F. P. Tally, J. Med. Chem. 37:184-188, 1994; R. T. Testa, P. Petersen, N. V. Jacobus, P. E. Sum, V. J. Lee, and F. P. Tally, Antimicrob. Agents Chemother. 37:2270-2277, 1993). Mutations in either of two codons of tetA(B) that resulted in increased resistance to DMG-Mino also caused diminished resistance to tetracycline, identifying amino acid residues critical for the recognition of tetracycline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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