Abstract
Lasalocid, sinefungin, and dehydroepiandrosterone were tested for anticryptosporidial activity with an immunodeficient mouse model at doses that have been reported effective when tested with immunosuppressed rodent models. Small but significant reductions in oocyst excretion were only observed under some conditions with lasalocid and dehydroepiandrosterone, but sinefungin had no effect.
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Selected References
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- Armitage K., Flanigan T., Carey J., Frank I., MacGregor R. R., Ross P., Goodgame R., Turner J. Treatment of cryptosporidiosis with paromomycin. A report of five cases. Arch Intern Med. 1992 Dec;152(12):2497–2499. [PubMed] [Google Scholar]
- Arrowood M. J., Sterling C. R. Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients. J Parasitol. 1987 Apr;73(2):314–319. [PubMed] [Google Scholar]
- Brasseur P., Lemeteil D., Ballet J. J. Anti-cryptosporidial drug activity screened with an immunosuppressed rat model. J Protozool. 1991 Nov-Dec;38(6):230S–231S. [PubMed] [Google Scholar]
- Brasseur P., Lemeteil D., Ballet J. J. Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model. Antimicrob Agents Chemother. 1993 Apr;37(4):889–892. doi: 10.1128/aac.37.4.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Current W. L., Garcia L. S. Cryptosporidiosis. Clin Lab Med. 1991 Dec;11(4):873–897. [PubMed] [Google Scholar]
- Goodgame R. W., Genta R. M., White A. C., Chappell C. L. Intensity of infection in AIDS-associated cryptosporidiosis. J Infect Dis. 1993 Mar;167(3):704–709. doi: 10.1093/infdis/167.3.704. [DOI] [PubMed] [Google Scholar]
- Howard J. G. Manipulation of the immune response in parasitic infections. Parasitology. 1984 Aug;88(Pt 4):665–675. doi: 10.1017/s0031182000085589. [DOI] [PubMed] [Google Scholar]
- Kimata I., Uni S., Iseki M. Chemotherapeutic effect of azithromycin and lasalocid on Cryptosporidium infection in mice. J Protozool. 1991 Nov-Dec;38(6):232S–233S. [PubMed] [Google Scholar]
- Lemeteil D., Roussel F., Favennec L., Ballet J. J., Brasseur P. Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model. J Infect Dis. 1993 Mar;167(3):766–768. doi: 10.1093/infdis/167.3.766. [DOI] [PubMed] [Google Scholar]
- McGowan I., Hawkins A. S., Weller I. V. The natural history of cryptosporidial diarrhoea in HIV-infected patients. AIDS. 1993 Mar;7(3):349–354. doi: 10.1097/00002030-199303000-00007. [DOI] [PubMed] [Google Scholar]
- Mead J. R., Arrowood M. J., Sidwell R. W., Healey M. C. Chronic Cryptosporidium parvum infections in congenitally immunodeficient SCID and nude mice. J Infect Dis. 1991 Jun;163(6):1297–1304. doi: 10.1093/infdis/163.6.1297. [DOI] [PubMed] [Google Scholar]
- Portnoy D., Whiteside M. E., Buckley E., 3rd, MacLeod C. L. Treatment of intestinal cryptosporidiosis with spiramycin. Ann Intern Med. 1984 Aug;101(2):202–204. doi: 10.7326/0003-4819-101-2-202. [DOI] [PubMed] [Google Scholar]
- Rasmussen K. R., Arrowood M. J., Healey M. C. Effectiveness of dehydroepiandrosterone in reduction of cryptosporidial activity in immunosuppressed rats. Antimicrob Agents Chemother. 1992 Jan;36(1):220–222. doi: 10.1128/aac.36.1.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rasmussen K. R., Martin E. G., Healey M. C. Effects of dehydroepiandrosterone in immunosuppressed rats infected with Cryptosporidium parvum. J Parasitol. 1993 Jun;79(3):364–370. [PubMed] [Google Scholar]
- Rehg J. E. Anti-cryptosporidial activity of macrolides in immunosuppressed rats. J Protozool. 1991 Nov-Dec;38(6):228S–230S. [PubMed] [Google Scholar]
- Rehg J. E. Anticryptosporidial activity is associated with specific sulfonamides in immunosuppressed rats. J Parasitol. 1991 Apr;77(2):238–240. [PubMed] [Google Scholar]
- Tzipori S. Cryptosporidiosis in perspective. Adv Parasitol. 1988;27:63–129. doi: 10.1016/S0065-308X(08)60353-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ungar B. L., Burris J. A., Quinn C. A., Finkelman F. D. New mouse models for chronic Cryptosporidium infection in immunodeficient hosts. Infect Immun. 1990 Apr;58(4):961–969. doi: 10.1128/iai.58.4.961-969.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watanabe S., Shimosato Y., Kuroki M., Sato Y., Nakajima T. Transplantability of human lymphoid cell line, lymphoma, and leukemia in splenectomized and/or irradiated nude mice. Cancer Res. 1980 Jul;40(7):2588–2595. [PubMed] [Google Scholar]
