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. 1994 Apr;38(4):883–885. doi: 10.1128/aac.38.4.883

In vivo bactericidal activities of ciprofloxacin and pefloxacin in an experimental model of Serratia marcescens endocarditis.

M E Juvin 1, G Potel 1, J Caillon 1, Y Q Xiong 1, D Bugnon 1, P Le Conte 1, D I Baron 1, H B Drugeon 1
PMCID: PMC284562  PMID: 8031065

Abstract

The critical concentrations of pefloxacin and ciprofloxacin in serum, corresponding to the lowest concentration in serum able to achieve a 2-log-unit reduction in the CFU in vegetations after a 24-h exposure at a steady-state concentration obtained by a continuous intravenous infusion, were determined in an experimental model of Serratia marcescens endocarditis in rabbits. In vitro data showed that the MICs of ciprofloxacin and pefloxacin were 0.06 and 0.25 mg/liter, respectively. The killing curves indicated a maximum killing rate at a concentration four times that of the MICs. In vivo, the critical concentrations of pefloxacin and ciprofloxacin in serum were 0.4 and 0.24 mg/liter, respectively, corresponding to a concentration of four times the MICs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borner K., Höffken G., Lode H., Koeppe P., Prinzing C., Glatzel P., Wiley R., Olschewski P., Sievers B., Reinitz D. Pharmacokinetics of ciprofloxacin in healthy volunteers after oral and intravenous administration. Eur J Clin Microbiol. 1986 Apr;5(2):179–186. doi: 10.1007/BF02013983. [DOI] [PubMed] [Google Scholar]
  2. Chalkley L. J., Koornhof H. J. Antimicrobial activity of ciprofloxacin against Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus determined by the killing curve method: antibiotic comparisons and synergistic interactions. Antimicrob Agents Chemother. 1985 Aug;28(2):331–342. doi: 10.1128/aac.28.2.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cremieux A. C., Carbon C. Pharmacokinetic and pharmacodynamic requirements for antibiotic therapy of experimental endocarditis. Antimicrob Agents Chemother. 1992 Oct;36(10):2069–2074. doi: 10.1128/aac.36.10.2069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Drugeon H. B., Caillon J., Juvin M. E., Pirault J. L. Dynamics of ceftazidime-pefloxacin interaction shown by a new killing curve-chequerboard method. J Antimicrob Chemother. 1987 Feb;19(2):197–203. doi: 10.1093/jac/19.2.197. [DOI] [PubMed] [Google Scholar]
  5. Gilchrist J. E., Campbell J. E., Donnelly C. B., Peeler J. T., Delaney J. M. Spiral plate method for bacterial determination. Appl Microbiol. 1973 Feb;25(2):244–252. doi: 10.1128/am.25.2.244-252.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Leggett J. E., Fantin B., Ebert S., Totsuka K., Vogelman B., Calame W., Mattie H., Craig W. A. Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models. J Infect Dis. 1989 Feb;159(2):281–292. doi: 10.1093/infdis/159.2.281. [DOI] [PubMed] [Google Scholar]
  7. Lewin C. S., Morrissey I., Smith J. T. The mode of action of quinolones: the paradox in activity of low and high concentrations and activity in the anaerobic environment. Eur J Clin Microbiol Infect Dis. 1991 Apr;10(4):240–248. doi: 10.1007/BF01966996. [DOI] [PubMed] [Google Scholar]
  8. Perlman B. B., Freedman L. R. Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. Yale J Biol Med. 1971 Oct;44(2):206–213. [PMC free article] [PubMed] [Google Scholar]
  9. Phillips I., King A. Comparative activity of the 4-quinolones. Rev Infect Dis. 1988 Jan-Feb;10 (Suppl 1):S70–S76. doi: 10.1093/clinids/10.supplement_1.s70. [DOI] [PubMed] [Google Scholar]
  10. Potel G., Caillon J., Le Gallou F., Bugnon D., Le Conte P., Raza J., Lepage J. Y., Baron D., Drugeon H. Identification of factors affecting in vivo aminoglycoside activity in an experimental model of gram-negative endocarditis. Antimicrob Agents Chemother. 1992 Apr;36(4):744–750. doi: 10.1128/aac.36.4.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Potel G., Chau N. P., Pangon B., Fantin B., Vallois J. M., Faurisson F., Carbon C. Single daily dosing of antibiotics: importance of in vitro killing rate, serum half-life, and protein binding. Antimicrob Agents Chemother. 1991 Oct;35(10):2085–2090. doi: 10.1128/aac.35.10.2085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rudin J. E., Norden C. W., Shinners E. M. In vitro activity of ciprofloxacin against aerobic gram-negative bacteria. Antimicrob Agents Chemother. 1984 Oct;26(4):597–598. doi: 10.1128/aac.26.4.597. [DOI] [PMC free article] [PubMed] [Google Scholar]

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