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. 1994 Apr;38(4):905–907. doi: 10.1128/aac.38.4.905

Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues.

S J Incavo 1, P J Ronchetti 1, J H Choi 1, H Wu 1, M Kinzig 1, F Sörgel 1
PMCID: PMC284568  PMID: 8031071

Abstract

The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 +/- 1.8 in cancellous bone tissue and 8.0 +/- 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentrations in bone and plasma for cancellous and cortical tissue were 23 and 18%, respectively, for piperacillin and 26 and 22%, respectively, for tazobactam. The concentrations of tazobactam achieved are sufficient to exert anti-beta-lactamase activity and supportive of clinical trials involving bone and joint infections, including those caused by beta-lactamase-producing pathogens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adam D., Heilmann H. D., Weismeier K. Concentrations of ticarcillin and clavulanic acid in human bone after prophylactic administration of 5.2 g of timentin. Antimicrob Agents Chemother. 1987 Jun;31(6):935–939. doi: 10.1128/aac.31.6.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aronoff S. C., Jacobs M. R., Johenning S., Yamabe S. Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Antimicrob Agents Chemother. 1984 Oct;26(4):580–582. doi: 10.1128/aac.26.4.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cars O. Pharmacokinetics of antibiotics in tissues and tissue fluids: a review. Scand J Infect Dis Suppl. 1990;74:23–33. [PubMed] [Google Scholar]
  4. Fortner C. L., Finley R. S., Schimpff S. C. Piperacillin sodium: antibacterial spectrum, pharmacokinetics, clinical efficacy, and adverse reactions. Pharmacotherapy. 1982 Nov-Dec;2(6):287–299. doi: 10.1002/j.1875-9114.1982.tb03202.x. [DOI] [PubMed] [Google Scholar]
  5. Grimer R. J., Karpinski M. R., Andrews J. M., Wise R. Penetration of amoxycillin and clavulanic acid into bone. Chemotherapy. 1986;32(3):185–191. doi: 10.1159/000238414. [DOI] [PubMed] [Google Scholar]
  6. Jones R. N., Pfaller M. A., Fuchs P. C., Aldridge K., Allen S. D., Gerlach E. H. Piperacillin/tazobactam (YTR 830) combination. Comparative antimicrobial activity against 5889 recent aerobic clinical isolates and 60 Bacteroides fragilis group strains. Diagn Microbiol Infect Dis. 1989 Nov-Dec;12(6):489–494. [PubMed] [Google Scholar]
  7. Kinzig M., Sörgel F., Brismar B., Nord C. E. Pharmacokinetics and tissue penetration of tazobactam and piperacillin in patients undergoing colorectal surgery. Antimicrob Agents Chemother. 1992 Sep;36(9):1997–2004. doi: 10.1128/aac.36.9.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ryan D. M., Cars O. A problem in the interpretation of beta-lactam antibiotic levels in tissues. J Antimicrob Chemother. 1983 Sep;12(3):281–284. doi: 10.1093/jac/12.3.281. [DOI] [PubMed] [Google Scholar]
  9. Sörgel F., Kinzig M. The chemistry, pharmacokinetics and tissue distribution of piperacillin/tazobactam. J Antimicrob Chemother. 1993 Jan;31 (Suppl A):39–60. doi: 10.1093/jac/31.suppl_a.39. [DOI] [PubMed] [Google Scholar]
  10. Weismeier K., Adam D., Heilmann H. D., Koeppe P. Penetration of amoxycillin/clavulanate into human bone. J Antimicrob Chemother. 1989 Nov;24 (Suppl B):93–100. doi: 10.1093/jac/24.suppl_b.93. [DOI] [PubMed] [Google Scholar]
  11. Winston D. J., Murphy W., Young L. S., Hewitt W. L. Piperacillin therapy for serious bacterial infections. Am J Med. 1980 Aug;69(2):255–261. doi: 10.1016/0002-9343(80)90386-1. [DOI] [PubMed] [Google Scholar]

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