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. 1994 Jul;38(7):1608–1614. doi: 10.1128/aac.38.7.1608

Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.

M Galleni 1, N Franceschini 1, B Quinting 1, L Fattorini 1, G Orefici 1, A Oratore 1, J M Frère 1, G Amicosante 1
PMCID: PMC284600  PMID: 7979294

Abstract

Sixteen different compounds usually considered beta-lactamase stable or representing potential beta-lactam inhibitors and inactivators were tested against the beta-lactamase produced by Mycobacterium fortuitum. The compounds exhibiting the most interesting properties were BRL42715, which was by far the best inactivator, and CGP31608 and ceftazidime, which were not recognized by the enzyme. These compounds thus exhibited adequate properties for fighting mycobacterial infections. Although cloxacillin, dicloxacillin, cefoxitin, and CP65207-2 exhibited poor inhibitory efficiency against the enzyme, they were also rather poor substrates and might be considered potential antimycobacterial agents. By contrast, CGP31523A and ceftamet were good substrates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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