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. 1994 Jul;38(7):1649–1650. doi: 10.1128/aac.38.7.1649

Production of A and C variants of staphylococcal beta-lactamase by methicillin-resistant strains of Staphylococcus aureus.

S R Norris 1, C W Stratton 1, D S Kernodle 1
PMCID: PMC284608  PMID: 7979301

Abstract

Most methicillin-resistant Staphylococcus aureus (MRSA) strains produce beta-lactamase. To determine whether this enzyme(s) is identical to one or more of the four beta-lactamases produced by methicillin-susceptible strains, the beta-lactamases of 50 MRSA isolates were typed by using substrate profile analysis. Forty type A, no type B, ten type C, and no type D beta-lactamase-producing strains were identified. The beta-lactamase inhibitor sulbactam reduced the MICs of beta-lactamase-labile antibiotics, including ampicillin, penicillin G, and cefazolin, for type A and type C MRSA strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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