Abstract
A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of paromomycin per kg of body weight per day.
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Selected References
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- Armitage K., Flanigan T., Carey J., Frank I., MacGregor R. R., Ross P., Goodgame R., Turner J. Treatment of cryptosporidiosis with paromomycin. A report of five cases. Arch Intern Med. 1992 Dec;152(12):2497–2499. [PubMed] [Google Scholar]
- Brasseur P., Lemeteil D., Ballet J. J. Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model. Antimicrob Agents Chemother. 1993 Apr;37(4):889–892. doi: 10.1128/aac.37.4.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clezy K., Gold J., Blaze J., Jones P. Paromomycin for the treatment of cryptosporidial diarrhoea in AIDS patients. AIDS. 1991 Sep;5(9):1146–1147. [PubMed] [Google Scholar]
- Current W. L., Garcia L. S. Cryptosporidiosis. Clin Microbiol Rev. 1991 Jul;4(3):325–358. doi: 10.1128/cmr.4.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fayer R., Ellis W. Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice. J Parasitol. 1993 Aug;79(4):553–558. [PubMed] [Google Scholar]
- Fayer R., Ellis W. Paromomycin is effective as prophylaxis for cryptosporidiosis in dairy calves. J Parasitol. 1993 Oct;79(5):771–774. [PubMed] [Google Scholar]
- Fichtenbaum C. J., Ritchie D. J., Powderly W. G. Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS. Clin Infect Dis. 1993 Feb;16(2):298–300. doi: 10.1093/clind/16.2.298. [DOI] [PubMed] [Google Scholar]
- Marshall R. J., Flanigan T. P. Paromomycin inhibits Cryptosporidium infection of a human enterocyte cell line. J Infect Dis. 1992 Apr;165(4):772–774. doi: 10.1093/infdis/165.4.772. [DOI] [PubMed] [Google Scholar]
- Rehg J. E. Activity of azithromycin against cryptosporidia in immunosuppressed rats. J Infect Dis. 1991 Jun;163(6):1293–1296. doi: 10.1093/infdis/163.6.1293. [DOI] [PubMed] [Google Scholar]
- Rehg J. E., Hancock M. L., Woodmansee D. B. Characterization of a dexamethasone-treated rat model of cryptosporidial infection. J Infect Dis. 1988 Dec;158(6):1406–1407. doi: 10.1093/infdis/158.6.1406. [DOI] [PubMed] [Google Scholar]