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. 1994 Aug;38(8):1859–1861. doi: 10.1128/aac.38.8.1859

Pneumocystis carinii is resistant to imidazole antifungal agents.

M S Bartlett 1, S F Queener 1, M M Shaw 1, J D Richardson 1, J W Smith 1
PMCID: PMC284650  PMID: 7986021

Abstract

Because Pneumocystis carinii is closely related to fungi, drugs useful for treating mycoses have been considered for use in the treatment of P. carinii pneumonia. Six antifungal imidazole drugs were tested for their activities against P. carinii in a short-term culture screen and in animals. None of the imidazoles tested was effective in inoculated infected rats, and only miconazole showed slight effects in culture at the high concentration of 10 micrograms/ml. Analysis of cell membranes from culture-grown P. carinii showed that ergosterol, the target for this class of antifungal agents, was absent, so that the lack of effect of these agents is rational.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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