Abstract
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. Replication of virus in the lower respiratory tract was also reduced > 100-fold, but three doses were required to prevent replication in the lungs. In ferrets infected with influenza B virus, single-dose treatment (40 mg/kg given intraperitoneally) produced a similar but reduced response in comparison with that in ferrets infected with influenza A virus, indicating that dosing was not optimal for this virus.
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Selected References
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- Alford R. H., Kasel J. A., Gerone P. J., Knight V. Human influenza resulting from aerosol inhalation. Proc Soc Exp Biol Med. 1966 Jul;122(3):800–804. doi: 10.3181/00379727-122-31255. [DOI] [PubMed] [Google Scholar]
- Basarab O., Smith H. Quantitative studies on the tissue localization of influenza virus in ferrets after intranasal and intravenous or intracardial inoculation. Br J Exp Pathol. 1969 Dec;50(6):612–618. [PMC free article] [PubMed] [Google Scholar]
- Campbell D., Sweet C., Hay A. J., Douglas A., Skehel J. J., Mason T. J., Smith H. Genetic composition and virulence of influenza virus: differences in facets of virulence in ferrets between two pairs of recombinants with RNA segments of the same parental origin. J Gen Virol. 1982 Feb;58(Pt 2):387–398. doi: 10.1099/0022-1317-58-2-387. [DOI] [PubMed] [Google Scholar]
- Jakeman K. J., Smith H., Sweet C. Mechanism of immunity to influenza: maternal and passive neonatal protection following immunization of adult ferrets with a live vaccinia-influenza virus haemagglutinin recombinant but not with recombinants containing other influenza virus proteins. J Gen Virol. 1989 Jun;70(Pt 6):1523–1531. doi: 10.1099/0022-1317-70-6-1523. [DOI] [PubMed] [Google Scholar]
- Smith H., Sweet C. Lessons for human influenza from pathogenicity studies with ferrets. Rev Infect Dis. 1988 Jan-Feb;10(1):56–75. doi: 10.1093/clinids/10.1.56. [DOI] [PubMed] [Google Scholar]
- Sweet C., Hayden F. G., Jakeman K. J., Grambas S., Hay A. J. Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets. J Infect Dis. 1991 Nov;164(5):969–972. doi: 10.1093/infdis/164.5.969. [DOI] [PubMed] [Google Scholar]
- Sweet C., Stephen J., Smith H. Purification of influenza viruses using disulphide-linked immunosorbents derived from rabbit antibody. Immunochemistry. 1974 Jun;11(6):295–304. doi: 10.1016/0019-2791(74)90365-6. [DOI] [PubMed] [Google Scholar]
- Sweet C., Stephen J., Smith H. The behaviour of antigenically related influenza viruses of differing virulence on disulphide-linked immunosorbents. Immunochemistry. 1974 Dec;11(12):823–826. doi: 10.1016/0019-2791(74)90304-8. [DOI] [PubMed] [Google Scholar]
- Toms G. L., Bird R. A., Kingsman S. M., Sweet C., Smith H. The behaviour in ferrets of two closely related clones of influenza virus of differing virulence for man. Br J Exp Pathol. 1976 Feb;57(1):37–48. [PMC free article] [PubMed] [Google Scholar]
- Toms G. L., Davies J. A., Woodward C. G., Sweet C., Smith H. The relation of pyrexia and nasal inflammatory response to virus levels in nasal washings of ferrets infected with influenza viruses of differing virulence. Br J Exp Pathol. 1977 Aug;58(4):444–458. [PMC free article] [PubMed] [Google Scholar]