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. 1994 Sep;38(9):2073–2077. doi: 10.1128/aac.38.9.2073

Comparison of aminoglycoside pharmacokinetics in Asian, Hispanic, and Caucasian patients by using population pharmacokinetic methods.

S S Jhee 1, J P Burm 1, M A Gill 1
PMCID: PMC284686  PMID: 7811021

Abstract

A population pharmacokinetic model for aminoglycosides was developed from 24 Hispanic, 16 Asian, and 22 Caucasian patients. A nonparametric expectation maximization algorithm for population modeling was used. With this one-compartment model, the parameters were the slope of the apparent volume of distribution versus weight (VS) and the slope of the elimination rate constant versus the creatinine clearance rate (KS). The mean VS (+/- standard deviation) was not different at 0.264 (+/- 0.05), 0.248 (+/- 0.055), and 0.260 (+/- 0.080) liter/kg of body weight for Asian, Hispanic, and Caucasian populations, respectively (P > 0.10). The KS means +/- standard deviations were 0.00424 +/- 0.00129, 0.00404 +/- 0.00160 and 0.00394 0.00103 [h(ml/min/1.73 m2)]-1 +/- for Hispanic, Asian, and Caucasian populations, respectively. Again, there was no statistical difference among the groups (P > 0.10). In conclusion, there are no differences in aminoglycoside pharmacokinetics among Asian, Hispanic, and Caucasian patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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