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. 1994 Sep;38(9):2175–2179. doi: 10.1128/aac.38.9.2175

Substrate specificity of Epstein-Barr virus thymidine kinase.

P P Tung 1, W C Summers 1
PMCID: PMC284705  PMID: 7811040

Abstract

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epstein-Barr virus thymidine kinase.

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Selected References

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