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. 1994 Sep;38(9):2191–2193. doi: 10.1128/aac.38.9.2191

Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus.

C M Brandt 1, M S Rouse 1, B M Tallan 1, W R Wilson 1, J M Steckelberg 1
PMCID: PMC284709  PMID: 7811044

Abstract

Results of in vitro time-kill synergy studies using subinhibitory, inhibitory, or suprainhibitory concentrations of bactericidal agents were compared with treatment outcomes of experimental infective endocarditis due to a methicillin-susceptible strain of Staphylococcus aureus. For rifampin-cephalosporin combinations, in vitro synergy testing using recommended fractions of the MIC failed to predict antagonism in vivo while concentrations above the MIC corresponded with antagonism in vivo.

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Selected References

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