Table III.
Logistic regression examining the association between bleomycin sensitivity and breast cancer risk
| MSA categories (b/c) | Cases–controls | ORa (95% CI) | Cases–controls | ORa (95% CI) |
| All subjects | ||||
| Low (≤0.64) | 51/85 | 1.00 | ||
| High (>0.65) | 113/80 | 2.8 (1.7–4.5) | ||
| Hyposensitive (≤0.48) | 21/43 | 1.00 | ||
| Sensitive (0.49–0.86) | 73/80 | 2.0 (1.1–3.9) | ||
| Hypersensitive (≥0.87) | 70/42 | 3.8 (1.9–7.5) | ||
| P trend | <0.01 | |||
| White women | Black women | |||
| Low (≤0.64) | 41/65 | 1.00 | 6/17 | 1.00 |
| High (>0.65) | 84/61 | 2.4 (1.4–4.2) | 23/14 | 6.9 (1.7–28.1) |
| Hyposensitive (≤0.48) | 17/36 | 1.00 | 2/6 | 1.00 |
| Sensitive (0.49–0.86) | 54/58 | 2.0 (1.0–4.2) | 15/17 | 3.8 (0.6–27.0) |
| Hypersensitive (≥0.87) | 54/32 | 3.8 (1.7–8.1) | 12/8 | 6.9 (0.9–54.3) |
| P trend | <0.01 | 0.07 | ||
| Premenopausal women | Postmenopausal women | |||
| Low (≤0.64) | 25/47 | 1.00 | 22/38 | 1.00 |
| High (>0.65) | 43/27 | 3.3 (1.6–6.9) | 65/51 | 2.5 (1.3–5.0) |
| Hyposensitive (≤0.48) | 10/23 | 1.00 | 11/20 | 1.00 |
| Sensitive (0.49–0.86) | 33/35 | 2.7 (1.1–7.1) | 35/44 | 1.8 (0.7–4.7) |
| Hypersensitive (≥0.87) | 25/16 | 4.7 (1.7–13.3) | 41/25 | 3.7 (1.4–9.5) |
| P trend | <0.01 | <0.01 | ||
| Postmenopausal women only | Postmenopausal women only | |||
| Ever user of HRT | Never user of HRT | |||
| Low (≤0.64) | 11/26 | 1.00 | 9/12 | 1.00 |
| High (>0.65) | 31/29 | 2.6 (1.0–6.5) | 31/22 | 1.9 (0.6–6.0) |
| Hyposensitive (≤0.48) | 5/14 | 1.00 | 5/6 | 1.00 |
| Sensitive (0.49–0.86) | 19/26 | 2.7 (0.7–10.0) | 15/18 | 1.2 (0.3–5.1) |
| Hypersensitive (≥0.87) | 18/15 | 4.2 (1.1–16.0) | 20/10 | 2.2 (0.5–10.5) |
| P trend | 0.03 | 0.23 | ||
| Ever smokers | Never smokers | |||
| Low (≤0.64) | 18/38 | 1.00 | 30/47 | 1.00 |
| High (>0.65) | 40/32 | 3.5 (1.5–8.0) | 71/46 | 2.4 (1.3–4.6) |
| Hyposensitive (≤0.48) | 8/19 | 1.00 | 12/24 | 1.00 |
| Sensitive (0.49–0.86) | 19/33 | 1.6 (0.6–4.7) | 51/46 | 2.3 (1.0–5.4) |
| Hypersensitive (≥0.87) | 31/18 | 6.4 (2.0–20.2) | 38/23 | 2.7 (1.1–6.8) |
| P trend | <0.01 | 0.04 | ||
b/c, breaks per cell.
a
Adjusted for age at interview, race (when appropriate), physical activity at teens, environmental tobacco smoking at work and menopausal status (when appropriate).