Abstract
The nucleotide sequence of the gene encoding a novel cephalosporinase (LAT-1), carried by a non-self-transferable plasmid from Klebsiella pneumoniae, has been determined. It was found that the sequence shares a high degree of homology with the Citrobacter freundii OS60 ampC structural gene.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bauernfeind A., Chong Y., Schweighart S. Extended broad spectrum beta-lactamase in Klebsiella pneumoniae including resistance to cephamycins. Infection. 1989 Sep-Oct;17(5):316–321. doi: 10.1007/BF01650718. [DOI] [PubMed] [Google Scholar]
- Fosberry A. P., Payne D. J., Lawlor E. J., Hodgson J. E. Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS. Antimicrob Agents Chemother. 1994 May;38(5):1182–1185. doi: 10.1128/aac.38.5.1182. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horii T., Arakawa Y., Ohta M., Ichiyama S., Wacharotayankun R., Kato N. Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam. Antimicrob Agents Chemother. 1993 May;37(5):984–990. doi: 10.1128/aac.37.5.984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindberg F., Normark S. Sequence of the Citrobacter freundii OS60 chromosomal ampC beta-lactamase gene. Eur J Biochem. 1986 May 2;156(3):441–445. doi: 10.1111/j.1432-1033.1986.tb09601.x. [DOI] [PubMed] [Google Scholar]
- Lindquist S., Lindberg F., Normark S. Binding of the Citrobacter freundii AmpR regulator to a single DNA site provides both autoregulation and activation of the inducible ampC beta-lactamase gene. J Bacteriol. 1989 Jul;171(7):3746–3753. doi: 10.1128/jb.171.7.3746-3753.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Papanicolaou G. A., Medeiros A. A., Jacoby G. A. Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother. 1990 Nov;34(11):2200–2209. doi: 10.1128/aac.34.11.2200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Payne D. J., Woodford N., Amyes S. G. Characterization of the plasmid mediated beta-lactamase BIL-1. J Antimicrob Chemother. 1992 Aug;30(2):119–127. doi: 10.1093/jac/30.2.119. [DOI] [PubMed] [Google Scholar]
- Philippon A., Labia R., Jacoby G. Extended-spectrum beta-lactamases. Antimicrob Agents Chemother. 1989 Aug;33(8):1131–1136. doi: 10.1128/aac.33.8.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tsukamoto K., Nishida N., Tsuruoka M., Sawai T. Function of the conserved triad residues in the class C beta-lactamase from Citrobacter freundii GN346. FEBS Lett. 1990 Oct 1;271(1-2):243–246. doi: 10.1016/0014-5793(90)80416-g. [DOI] [PubMed] [Google Scholar]
- Tsukamoto K., Tachibana K., Yamazaki N., Ishii Y., Ujiie K., Nishida N., Sawai T. Role of lysine-67 in the active site of class C beta-lactamase from Citrobacter freundii GN346. Eur J Biochem. 1990 Feb 22;188(1):15–22. doi: 10.1111/j.1432-1033.1990.tb15365.x. [DOI] [PubMed] [Google Scholar]
- Tzouvelekis L. S., Tzelepi E., Mentis A. F., Tsakris A. Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae. J Antimicrob Chemother. 1993 May;31(5):645–654. doi: 10.1093/jac/31.5.645. [DOI] [PubMed] [Google Scholar]
- Yamaguchi A., Adachi H., Sawai T. Identification of the active site of Citrobacter freundii beta-lactamase using dansyl-penicillin. FEBS Lett. 1987 Jun 22;218(1):126–130. doi: 10.1016/0014-5793(87)81031-1. [DOI] [PubMed] [Google Scholar]