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. 1994 Oct;38(10):2483–2487. doi: 10.1128/aac.38.10.2483

Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.

L Guo 1, N K Heinzinger 1, M Stevenson 1, L M Schopfer 1, J M Salhany 1
PMCID: PMC284769  PMID: 7530934

Abstract

Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.

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Selected References

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