Abstract
A cell-free crude extract of Erysipelothrix rhusiopathiae injected by high pressure jet into the knee-joint of rabbits stimulated an acute, mild inflammatory reaction. Additional injections at 3-day intervals induced a chronic condition characterized by hyperplasia of the synovial cells and hypertrophy of the villi, due to infiltration by lymphocytes and plasma cells which formed aggregates resembling Allison-Ghormley bodies. There was also extensive proliferation of stroma vasculature and fibrous tissue. A similar jet injection of the diluent produced an early, transient, acute, and mild inflammation. A mechanism is postulated for fixation of one or more of the chemically characterized antigens in or near the synovium as a means of inducing the localized inflammatory response that predisposes the joint to infection.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- FREEMAN M. J. EFFECTS OF VACCINATION ON THE DEVELOPMENT OF ARTHRITIS IN SWINE WITH ERYSIPELAS: CLINICAL, HEMATOLOGIC, AND GROSS PATHOLOGIC OBSERVATIONS. Am J Vet Res. 1964 May;25:589–598. [PubMed] [Google Scholar]
- Gardner D. L. The Experimental Production of Arthritis: A Review. Ann Rheum Dis. 1960 Dec;19(4):297–317. doi: 10.1136/ard.19.4.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KALF G. A., GRECE M. A. THE ANTIGENIC COMPONENTS OF ERYSIPELOTHRIX RHUSIOPATHIAE. 3. PURIFICATION OF B- AND C-ANTIGENS. Arch Biochem Biophys. 1964 Jul;107:141–146. doi: 10.1016/0003-9861(64)90281-4. [DOI] [PubMed] [Google Scholar]
- KALF G. F., WHITE T. G. The antigenic components of Erysipelothrix rhusiopathiae. II. Purification and chemical characterization of a type-specific antigen. Arch Biochem Biophys. 1963 Jul;102:39–47. doi: 10.1016/0003-9861(63)90317-5. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Schwab J. H., Cromartie W. J., Ohanian S. H., Craddock J. G. Association of experimental chronic arthritis with the persistence of group A streptococcal cell walls in the articular tissue. J Bacteriol. 1967 Nov;94(5):1728–1735. doi: 10.1128/jb.94.5.1728-1735.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shuman R. D., Wood R. L., Monlux W. S. Sensitization by Erysipelothrix rhusiopathiae (insidiosa) with relation to arthritis in pigs. V. Pretreatment with live cells and challenge with homologous, heterologous, or isologous live cells. Cornell Vet. 1965 Oct;55(4):523–534. [PubMed] [Google Scholar]
- WEISSMANN G., BECHER B., WIEDERMANN G., BERNHEIMER A. W. STUDIES ON LYSOSOMES. VII. ACUTE AND CHRONIC ARTHRITIS PRODUCED BY INTRA-ARTICULAR INJECTIONS OF STREPTOLYSIN S IN RABBITS. Am J Pathol. 1965 Jan;46:129–147. [PMC free article] [PubMed] [Google Scholar]
- WHITE T. G., KALF G. F. The antigenic components of Erysipelothrix rhusiopathiae. I. Isolation and serological identification. Arch Biochem Biophys. 1961 Dec;95:458–463. doi: 10.1016/0003-9861(61)90176-x. [DOI] [PubMed] [Google Scholar]
- Willkens R. F., Anderson R. V., Gilliland B. C. Response of sensitized rabbits to intra-articular gamma globulin. Arthritis Rheum. 1968 Jun;11(3):418–425. doi: 10.1002/art.1780110307. [DOI] [PubMed] [Google Scholar]