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. 1969 May;98(2):447–452. doi: 10.1128/jb.98.2.447-452.1969

Erythromycin-inducible Resistance in Staphylococcus aureus: Survey of Antibiotic Classes Involved

Bernard Weisblum 1, Veronika Demohn 1
PMCID: PMC284837  PMID: 5784204

Abstract

Certain erythromycin-resistant strains of Staphylococcus aureus remain sensitive to other macrolide antibiotics. If these strains are exposed to low levels of erythromycin, resistance to other antibiotics is induced. The antibiotics to which resistance is induced by erythromycin include: other macrolides as well as lincosaminide, streptogramin (group B) antibiotics but not chloramphenicol, amicetin, streptogramin (group A) antibiotics, tetracyclines, and aminoglycosides. Hence erythromycin induces resistance exclusively towards inhibitors of 50S ribosomal subunit function and, thus far, only with respect to three of six known classes of inhibitors which act on this subunit. In the four strains tested, erythromycin did not induce resistance to pactamycin or bottromycin, to fusidic acid (which inhibits a function involving both subunits), or to other antibiotics which do not inhibit ribosomal function. Thus, by inducing resistance erythromycin could antagonize the action of other antibiotics, and a consistent pattern of antagonism was observed to each antibiotic class in all of the strains in which this could be tested, as well as to other antibiotic members of the same chemical class in each bacterial strain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARBER M., WATERWORTH P. M. ANTIBACTERIAL ACTIVITY OF LINCOMYCIN AND PRISTINAMYCIN: A COMPARISON WITH ERYTHROMYCIN. Br Med J. 1964 Sep 5;2(5409):603–606. doi: 10.1136/bmj.2.5409.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CHABBERT Y. Antagonisme in vitro entre l'érythromycine et la spiramycine. Ann Inst Pasteur (Paris) 1956 Jun;90(6):787–790. [PubMed] [Google Scholar]
  3. Chang F. N., Sih C. J., Weisblum B. Lincomycin, an inhibitor of aminoacyl sRNA binding to ribosomes. Proc Natl Acad Sci U S A. 1966 Feb;55(2):431–438. doi: 10.1073/pnas.55.2.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DAVIES J. E. STUDIES ON THE RIBOSOMES OF STREPTOMYCIN-SENSITIVE AND RESISTANT STRAINS OF ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1964 Apr;51:659–664. doi: 10.1073/pnas.51.4.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GARROD L. P. The erythromycin group of antibiotics. Br Med J. 1957 Jul 13;2(5036):57–63. doi: 10.1136/bmj.2.5036.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GRIFFITH L. J., OSTRANDER W. E., MULLINS C. G., BESWICK D. E. DRUG ANTAGONISM BETWEEN LINCOMYCIN AND ERYTHROMYCIN. Science. 1965 Feb 12;147(3659):746–747. doi: 10.1126/science.147.3659.746. [DOI] [PubMed] [Google Scholar]
  7. Hashimoto H., Oshima H., Mitsuhashi S. Drug resistance of staphylococci. IX. Inducible resistance to macrolide antibiotics in Staphylococcus aureus. Jpn J Microbiol. 1968 Sep;12(3):321–327. [PubMed] [Google Scholar]
  8. Nakajima Y., Inoue M., Oka Y., Yamagishi S. A mode of resistance to macrolide antibiotics in Staphylococcus aureus. Jpn J Microbiol. 1968 Jun;12(2):248–250. doi: 10.1111/j.1348-0421.1968.tb00390.x. [DOI] [PubMed] [Google Scholar]
  9. PATTEE P. A., BALDWIN J. N. Transduction of resistance to some macrolide antibiotics in Staphylococcus aureus. J Bacteriol. 1962 Nov;84:1049–1055. doi: 10.1128/jb.84.5.1049-1055.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sabath L. D., Gerstein D. A., Loder P. B., Finland M. Independent segregation of chloramphenicol resistance in Staphylococcus aureus. Antimicrob Agents Chemother (Bethesda) 1967;7:264–270. [PubMed] [Google Scholar]
  11. Taubman S. B., Jones N. R., Young F. E., Corcoran J. W. Sensitivity and resistance to erythromycin in Bacillus subtilis 168: the ribosomal binding of erythromycin and chloramphenicol. Biochim Biophys Acta. 1966 Aug 17;123(2):438–440. doi: 10.1016/0005-2787(66)90301-7. [DOI] [PubMed] [Google Scholar]
  12. Vazquez D. Binding of chloramphenicol to ribosomes. The effect of a number of antibiotics. Biochim Biophys Acta. 1966 Feb 21;114(2):277–288. doi: 10.1016/0005-2787(66)90309-1. [DOI] [PubMed] [Google Scholar]
  13. Vazquez D. Binding to ribosomes and inhibitory effect on protein synthesis of the spiramycin antibiotics. Life Sci. 1967 Apr 15;6(8):845–853. doi: 10.1016/0024-3205(67)90287-1. [DOI] [PubMed] [Google Scholar]
  14. WEAVER J. R., PATTEE P. A. INDUCIBLE RESISTANCE TO ERYTHROMYCIN IN STAPHYLOCOCCUS AUREUS. J Bacteriol. 1964 Sep;88:574–580. doi: 10.1128/jb.88.3.574-580.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Weisblum B., Davies J. Antibiotic inhibitors of the bacterial ribosome. Bacteriol Rev. 1968 Dec;32(4 Pt 2):493–528. [PMC free article] [PubMed] [Google Scholar]

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