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. 1969 May;98(2):744–748. doi: 10.1128/jb.98.2.744-748.1969

Inhibitory Effect of 2-Deoxy-d-Glucose on the Formation of the Cell Wall in Yeast Protoplasts

V Farkaš a, A Svoboda a,1, Š Bauer a
PMCID: PMC284880  PMID: 5784222

Abstract

2-Deoxy-d-glucose (2DG) acted as a competitive inhibitor of the synthesis of cell wall components in Saccharomyces cerevisiae protoplasts. The synthesis of fibrillar glucan cell wall component was inhibited at a glucose to 2DG ratio of 4:1 in the cultivating medium. The completion of the formation of cell wall by the synthesis of the amorphous mannan-protein cell wall component was inhibited at a glucose to 2DG ratio of about 20:1. The inhibition could be reversed by increasing the glucose to 2DG ratio in the nutrient medium. No incorporation of 2DG into fibrillar glucan cell wall component was observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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