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. 1972 Feb;109(2):780–783. doi: 10.1128/jb.109.2.780-783.1972

Ribosomal Proteins Involved in the Suppression of Streptomycin Dependence in Escherichia coli

Gerald Kreider 1, Barbara L Brownstein 1
PMCID: PMC285205  PMID: 4258063

Abstract

Suppression of streptomycin dependence in Escherichia coli strain K-114, a spectinomycin-sensitive strain, is correlated with modification of 30S ribosomal protein P4, the component modified in spectinomycin-resistant mutants. The mutant is unusual in that reversion from dependence has previously been correlated only with modification in 30S protein P4a. Introduction into K-114 of another mutation conferring spectinomycin resistance results in a further alteration in protein P4.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birge E. A., Kurland C. G. Altered ribosomal protein in streptomycin-dependent Escherichia coli. Science. 1969 Dec 5;166(3910):1282–1284. doi: 10.1126/science.166.3910.1282. [DOI] [PubMed] [Google Scholar]
  2. Birge E. A., Kurland C. G. Reversion of a streptomycin-dependent strain of Escherichia coli. Mol Gen Genet. 1970;109(4):356–369. doi: 10.1007/BF00267704. [DOI] [PubMed] [Google Scholar]
  3. Bollen A., Davies J., Ozaki M., Mizushima S. Ribosomal Protein Conferring Sensitivity to the Antibiotic Spectinomycin in Escherichia coli. Science. 1969 Jul 4;165(3888):85–86. doi: 10.1126/science.165.3888.85. [DOI] [PubMed] [Google Scholar]
  4. Brownstein B. L., Lewandowski L. J. A mutation suppressing streptomycin dependence. I. An effect on ribosome function. J Mol Biol. 1967 Apr 14;25(1):99–109. doi: 10.1016/0022-2836(67)90281-1. [DOI] [PubMed] [Google Scholar]
  5. Chang F. N., Flaks J. G. Topography of the Escherichia coli 30S ribosomal subunit and streptomycin binding. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1321–1328. doi: 10.1073/pnas.67.3.1321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Deusser E., Stöffler G., Wittmann H. G. Ribosomal proteins. XVI. Altered S4 proteins in Escherichia coli revertants from streptomycin dependence to independence. Mol Gen Genet. 1970;109(4):298–302. doi: 10.1007/BF00267699. [DOI] [PubMed] [Google Scholar]
  7. Hardy S. J., Kurland C. G., Voynow P., Mora G. The ribosomal proteins of Escherichia coli. I. Purification of the 30S ribosomal proteins. Biochemistry. 1969 Jul;8(7):2897–2905. doi: 10.1021/bi00835a031. [DOI] [PubMed] [Google Scholar]
  8. Hashimoto K. Streptomycin Resistance in Escherichia Coli Analyzed by Transduction. Genetics. 1960 Jan;45(1):49–62. doi: 10.1093/genetics/45.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kaltschmidt E., Dzionara M., Wittmann H. G. Ribosomal proteins. XV. Amino acid compositions of isolated ribosomal proteins from 30S and 50S subunits of Escherichia coli. Mol Gen Genet. 1970;109(4):292–297. doi: 10.1007/BF00267698. [DOI] [PubMed] [Google Scholar]
  10. Kreider G., Brownstein B. L. A mutation suppressing streptomycin dependence. II. An altered protein on the 30 s ribosomal subunit. J Mol Biol. 1971 Oct 14;61(1):135–142. doi: 10.1016/0022-2836(71)90211-7. [DOI] [PubMed] [Google Scholar]
  11. Kuwano M., Endo H., Ohnishi Y. Mutations to spectinomycin resistance which alleviate the restriction of an amber suppressor by streptomycin resistance. J Bacteriol. 1969 Feb;97(2):940–943. doi: 10.1128/jb.97.2.940-943.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LENNOX E. S. Transduction of linked genetic characters of the host by bacteriophage P1. Virology. 1955 Jul;1(2):190–206. doi: 10.1016/0042-6822(55)90016-7. [DOI] [PubMed] [Google Scholar]
  13. Mizushima S., Nomura M. Assembly mapping of 30S ribosomal proteins from E. coli. Nature. 1970 Jun 27;226(5252):1214–1214. doi: 10.1038/2261214a0. [DOI] [PubMed] [Google Scholar]
  14. Nomura M., Mizushima S., Ozaki M., Traub P., Lowry C. V. Structure and function of ribosomes and their molecular components. Cold Spring Harb Symp Quant Biol. 1969;34:49–61. doi: 10.1101/sqb.1969.034.01.009. [DOI] [PubMed] [Google Scholar]
  15. Rosset R., Gorini L. A ribosomal ambiguity mutation. J Mol Biol. 1969 Jan 14;39(1):95–112. doi: 10.1016/0022-2836(69)90336-2. [DOI] [PubMed] [Google Scholar]
  16. Zimmermann R. A., Garvin R. T., Gorini L. Alteration of a 30S ribosomal protein accompanying the ram mutation in Escherichia coli. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2263–2267. doi: 10.1073/pnas.68.9.2263. [DOI] [PMC free article] [PubMed] [Google Scholar]

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