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(A) RDL extracellular domain dimer. Extracellular loops A−F that form the agonist binding site region in related Cys-loop receptors are labeled. (B) Sequence alignment of extracellular domains of RDL and homologous Cys-loop receptor subunits (human GABAA α1, human GABAA β2, mouse 5-HT3A, and AChBP).
