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. 1973 Feb;113(2):619–626. doi: 10.1128/jb.113.2.619-626.1973

Control of Pantothenate Accumulation in Agrobacterium tumefaciens

Tsuneo Kaneshiro a, Larry O Arthur a,1,2, Kenneth W Nickerson a,1
PMCID: PMC285273  PMID: 4347924

Abstract

Two pantothenate-requiring mutants of Agrobacterium tumefaciens have been isolated. One of them (strain WMP-1) is unusual in that growth levels equivalent to the parent strain are achieved only when the medium is additionally supplemented with aspartate or another compound related to the tricarboxylic acid cycle. Extracts of cells grown on limiting aspartate were found to contain four times more 14C-pantothenate than those grown at optimal aspartate concentrations. This difference was found in both the perchloric acid-soluble and -insoluble fractions, presumably the coenzyme A pool and acyl carrier protein, respectively. These findings are discussed in terms of membrane integrity and the control of fatty acid biosynthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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