Table 1.
Results of five published meta-analyses of randomised controlled trials on antibiotic prophylaxis for mortality and respiratory tract infection in patients in intensive care
| End points | Point estimates (95% CI)
|
||
|---|---|---|---|
| All trials | Topical plus systemic antibiotics | Topical antibiotics alone | |
| Vandenbroucke-Grauls et al4 (6 trials, 491 patients) | |||
| Mortality | 0.70* (0.45 to 1.09) | NA | NA |
| Infection | 0.12* (0.08 to 0.19) | NA | NA |
| SDD Trialists’ Group5 (22 trials, 4142 patients) | |||
| Mortality | 0.90* (0.79 to 1.04) | 0.80 (0.67 to 0.97) | 1.07 (0.86 to 1.32) |
| Infection | 0.37* (0.31 to 0.43) | 0.33 (0.27 to 0.40) | 0.43 (0.33 to 0.56) |
| Heyland et al6 (24 trials, 3312 patients) | |||
| Mortality | 0.87† (0.79 to 0.97) | 0.81 (0.71 to 0.95) | 1.00 (0.83 to 1.19) |
| Pneumonia | 0.46† (0.39 to 0.56) | 0.48 (0.39 to 0.60) | 0.43 (0.32 to 0.59) |
| Kollef et al8 (16 trials, 2270 patients) | |||
| Mortality | 0.02‡ (−0.02 to 0.05) | NA | NA |
| Pneumonia | 0.14‡ (0.12 to 0.17) | NA | NA |
| Tracheobronchitis | 0.05‡ (0.02 to 0.09) | NA | NA |
| Hurley et al7 (26 trials, 3768 patients) | |||
| Mortality | 0.86* (0.74 to 0.99) | NA | NA |
| Infection | 0.35* (0.30 to 0.42) | NA | NA |
NA=data not in published articles.
*
Odds ratio.
†
Relative risk.
‡
Risk difference.