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. 1973 Jun;114(3):966–973. doi: 10.1128/jb.114.3.966-973.1973

Replication of Deoxyribonucleic Acid During the Division Cycle of Salmonella typhimurium

Stephen Cooper 1, Therese Ruettinger 1
PMCID: PMC285352  PMID: 4576412

Abstract

The rate of thymidine incorporation into cells of Salmonella typhimurium growing in different media has been measured. In glucose-minimal medium, deoxyribonucleic acid (DNA) replication occurs during the first two-thirds of the division cycle; the final one-third of the division cycle was devoid of DNA replication. The measured doubling time of S. typhimurium in this medium is approximately 48 min, indicating that C (the time for a round of replication) and D (the time between termination and cell division) are approximately 32 and 16 min, respectively. At slower growth rates the pattern of replication is the same as glucose minimal medium. At faster growth rates the “gap” in DNA synthesis disappears. At rapid growth rates evidence for multiple forks is obtained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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