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. 1973 Nov;116(2):771–777. doi: 10.1128/jb.116.2.771-777.1973

Absence of Circular Plasmid Deoxyribonucleic Acid Attributable to a Genetic Determinant for Methicillin Resistance in Staphylococcus aureus

Paul W Stiffler 1,2, H M Sweeney 1,2, Sidney Cohen 1,2
PMCID: PMC285444  PMID: 4490525

Abstract

Plasmid deoxyribonucleic acid was not detected by centrifugal analysis of lysates of penicillinase-negative strains of Staphylococcus aureus harboring a determinant of methicillin resistance derived from strain Villaluz. When these strains contained a penicillinase plasmid, the plasmid deoxyribonucleic acid of methicillin-resistant and methicillin-susceptible strains was indistinguishable by the methods employed. The results indicate that the genetic determinant for methicillin resistance in the strains examined was not associated with a circular plasmid comparable to those that have been shown to determine resistance to benzylpenicillin, tetracycline, and chloramphenicol in S. aureus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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