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. 1974 Feb;117(2):432–438. doi: 10.1128/jb.117.2.432-438.1974

Cyclic Adenosine 3′,5′-Monophosphate and Morphogenesis in Mucor racemosus

Alf D Larsen 1, Paul S Sypherd 1
PMCID: PMC285530  PMID: 4359645

Abstract

Yeastlike cells of Mucor racemosus grown under 100% CO2 underwent morphogenesis to hyphae after exposure to air. The addition of dibutyryl cyclic adenosine monophosphate (dbcAMP) to yeastlike cultures inhibited this morphogenesis in media containing 2% glucose. The maintenance of uniformly spherical, budding cells required 1 mM dbcAMP in a defined medium containing Casamino Acids, and 3 mM dbcAMP in a medium containing yeast extract and peptone. At these concentrations, dbcAMP also induced yeastlike development in young aerobic hyphae grown in media containing 2% glucose. Removal of dbcAMP resulted in hyphal development. The endogenous cyclic AMP (cAMP) content of yeastlike cultures was measured after a shift from CO2 to air. A fourfold decrease in intracellular cAMP preceded the appearance of hyphal germ tubes. These results indicate that cAMP plays a role in the control of morphogenesis in Mucor racemosus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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