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. Author manuscript; available in PMC: 2010 Apr 19.
Published in final edited form as: Science. 2009 Sep 11;325(5946):1402–1405. doi: 10.1126/science.1173474

Fig. 2.

Fig. 2

gpr126 is essential for expression of oct6 and krox20 in Schwann cells. Whole mount in situ hybridization of (A) WT and (B) gpr126st49 mutant zebrafish larvae at 66 hpf showing sox10 mRNA expression in PLLn Schwann cells (arrow). (C) WT zebrafish embryo at 48 hpf showing oct6 expression in the brain (arrowhead) and in PLLn Schwann cells (arrow) as previously described (22). (D) gpr126st49 mutant embryo at 48 hpf showing normal oct6 expression in the brain (arrowhead) but not in PLLn Schwann cells (arrow). (E) WT zebrafish larva at 66 hpf showing krox20 mRNA expression in the brain (arrowhead) and in PLLn Schwann cells (arrow). (F) gpr126st49 mutant larva at 66 hpf showing normal krox20 expression in the brain (arrowhead) but not in PLLn Schwann cells (arrow). For (A–F), anterior is left and dorsal is up. Genotypes were determined by PCR after photography; see Fig. S7 for quantification of these experiments.