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. 1966 Jul;56(1):156–163. doi: 10.1073/pnas.56.1.156

The synthesis of homocystine, cystathionine, and cystine by cultured diploid and heteroploid human cells.

H Eagle, C Washington, S M Friedman
PMCID: PMC285689  PMID: 5229844

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Selected References

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  1. AUERSPERG N. LONG-TERM CULTIVATION OF HYPODIPLOID HUMAN TUMOR CELLS. J Natl Cancer Inst. 1964 Jan;32:135–163. [PubMed] [Google Scholar]
  2. CHILDS B., NYHAN W. L., BORDEN M., BARD L., COOKE R. E. Idiopathic hyperglycinemia and hyperglycinuria: a new disorder of amino acid metabolism. I. Pediatrics. 1961 Apr;27:522–538. [PubMed] [Google Scholar]
  3. DECARLI L., MAIO J. J., NUZZO F., BENERECETTI A. S. CYTOGENETIC STUDIES WITH ALKALINE PHOSPHATASE IN HUMAN HETEROPLOID CELLS. Cold Spring Harb Symp Quant Biol. 1964;29:223–231. doi: 10.1101/sqb.1964.029.01.026. [DOI] [PubMed] [Google Scholar]
  4. EAGLE H. Amino acid metabolism in mammalian cell cultures. Science. 1959 Aug 21;130(3373):432–437. doi: 10.1126/science.130.3373.432. [DOI] [PubMed] [Google Scholar]
  5. EAGLE H. METABOLIC CONTROLS IN CULTURED MAMMALIAN CELLS. Science. 1965 Apr 2;148(3666):42–51. doi: 10.1126/science.148.3666.42. [DOI] [PubMed] [Google Scholar]
  6. EAGLE H. Nutrition needs of mammalian cells in tissue culture. Science. 1955 Sep 16;122(3168):501–514. doi: 10.1126/science.122.3168.501. [DOI] [PubMed] [Google Scholar]
  7. EAGLE H., OYAMA V. I., PIEZ K. A. The reversible binding of half-cystine residues to serum protein, and its bearing on the cystine requirement of cultured mammalian cells. J Biol Chem. 1960 Jun;235:1719–1726. [PubMed] [Google Scholar]
  8. EAGLE H., PIEZ K. A., OYAMA V. I. The biosynthesis of cystine in human cell cultures. J Biol Chem. 1961 May;236:1425–1428. [PubMed] [Google Scholar]
  9. EAGLE H., PIEZ K. The population-dependent requirement by cultured mammalian cells for metabolites which they can synthesize. J Exp Med. 1962 Jul 1;116:29–43. doi: 10.1084/jem.116.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Eagle H., Washington C. L., Levy M. End product control of amino acid synthesis by cultured human cells. J Biol Chem. 1965 Oct;240(10):3944–3950. [PubMed] [Google Scholar]
  11. FAUTREZ J. [Correlation between the size of the nucleus and its DNA content]. Z Mikrosk Anat Forsch. 1960;66:210–224. [PubMed] [Google Scholar]
  12. FOGH J., LUND R. O. Continuous cultivation of epithelial cell strain (FL) from human amniotic membrane. Proc Soc Exp Biol Med. 1957 Mar;94(3):532–537. doi: 10.3181/00379727-94-23003. [DOI] [PubMed] [Google Scholar]
  13. FRIMPTER G. W., HAYMOVITZ A., HORWITH M. Cystathioninura. N Engl J Med. 1963 Feb 14;268:333–339. doi: 10.1056/NEJM196302142680701. [DOI] [PubMed] [Google Scholar]
  14. HARRIS H., PENROSE L. S., THOMAS D. H. Cystathioniuria. Ann Hum Genet. 1959 Dec;23:442–453. doi: 10.1111/j.1469-1809.1959.tb01485.x. [DOI] [PubMed] [Google Scholar]
  15. HAYFLICK L. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res. 1965 Mar;37:614–636. doi: 10.1016/0014-4827(65)90211-9. [DOI] [PubMed] [Google Scholar]
  16. HAYFLICK L. The establishment of a line (WISH) of human amnion cells in continuous cultivation. Exp Cell Res. 1961 Feb;23:14–20. doi: 10.1016/0014-4827(61)90059-3. [DOI] [PubMed] [Google Scholar]
  17. LEVINE E. M., BECKER Y., BOONE C. W., EAGLE H. CONTACT INHIBITION, MACROMOLECULAR SYNTHESIS, AND POLYRIBOSOMES IN CULTURED HUMAN DIPLOID FIBROBLASTS. Proc Natl Acad Sci U S A. 1965 Feb;53:350–356. doi: 10.1073/pnas.53.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. LOCKART R. Z., Jr, EAGLE H. Requirements for growth of single human cells. Science. 1959 Jan 30;129(3344):252–254. doi: 10.1126/science.129.3344.252. [DOI] [PubMed] [Google Scholar]
  19. MOORE A. E., SABACHEWSKY L., TOOLAN H. W. Culture characteristics of four permanent lines of human cancer cells. Cancer Res. 1955 Oct;15(9):598–602. [PubMed] [Google Scholar]
  20. MOORE G. E., SANDBERG A. A. STUDIES OF A HUMAN TUMOR CELL LINE WITH A DIPLOID KARYOTYPE. Cancer. 1964 Feb;17:170–175. doi: 10.1002/1097-0142(196402)17:2<170::aid-cncr2820170206>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  21. Moorhead P. S. Human tumor cell line with a quasi-diploid karyotype (RPMI 2650). Exp Cell Res. 1965 Aug;39(1):190–196. doi: 10.1016/0014-4827(65)90022-4. [DOI] [PubMed] [Google Scholar]
  22. Mudd S. H., Finkelstein J. D., Irreverre F., Laster L. Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway. J Biol Chem. 1965 Nov;240(11):4382–4392. [PubMed] [Google Scholar]
  23. NAORA H. Microspectrophotometry of cell nuclei stained with the Feulgen reaction. IV. Formation of tetraploid nuclei in rat liver cells during postnatal growth. J Biophys Biochem Cytol. 1957 Nov 25;3(6):949–975. doi: 10.1083/jcb.3.6.949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. NYHAN W. L., BORDEN M., CHILDS B. Idiopathic hyperglycinemia: a new disorder of amino acid metabolism. II. The concentrations of other amino acids in the plasma and their modification by the administration of leucine. Pediatrics. 1961 Apr;27:539–550. [PubMed] [Google Scholar]
  25. OYAMA V. I., EAGLE H. Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau). Proc Soc Exp Biol Med. 1956 Feb;91(2):305–307. doi: 10.3181/00379727-91-22245. [DOI] [PubMed] [Google Scholar]
  26. PIEZ K. A. Continuous scintillation counting of carbon-14 and tritium in effluent of the automatic amino acid analyzer. Anal Biochem. 1962 Dec;4:444–458. doi: 10.1016/0003-2697(62)90126-4. [DOI] [PubMed] [Google Scholar]
  27. SWIFT H. H. The desoxyribose nucleic acid content of animal nuclei. Physiol Zool. 1950 Jul;23(3):169–198. doi: 10.1086/physzool.23.3.30152074. [DOI] [PubMed] [Google Scholar]

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