Table 3.
Unadjusted
|
Adjusted
|
||||
---|---|---|---|---|---|
Odds ratio (95% CI) | P value | Odds ratio (95% CI)* | P value | ||
First diagnosis of anxiety or depression before diagnosis of heart disease | |||||
Depression† | 3.09 (1.33 to 7.21) | 0.009 | 2.75 (1.13 to 6.69) | 0.03 | |
Anxiety‡ | 1.62 (0.46 to 5.63) | 0.45 | 1.40 (0.37 to 5.25) | 0.62 | |
Duration of depression (years)§: | |||||
⩽10 | 3.13 (1.27 to 7.70) | 0.01 | 3.12 (1.23 to 7.93) | 0.02 | |
>10 | 2.18 (0.61 to 7.77) | 0.23 | 1.63 (0.41 to 6.44) | 0.048 | |
Tricyclic antidepressants¶ | 3.49 (0.95 to 12.85) | 0.06 | 3.55 (0.89 to 14.21) | 0.07 | |
Mean daily dose of tricyclic antidepressant¶: | |||||
<75 mg | 2.92 (0.61 to 13.91) | 0.18 | 2.97 (0.58 to 15.11) | 0.19 | |
⩾75 mg | 4.71 (0.70 to 31.77) | 0.11 | 5.02 (0.62 to 40.56) | 0.13 | |
Duration of tricyclic antidepressants (months)¶: | |||||
⩽4 | 5.07 (0.88 to 29.15) | 0.07 | 5.47 (0.84 to 35.50) | 0.08 | |
>4 | 2.27 (0.36 to 14.50) | 0.39 | 2.19 (0.31 to 15.49) | 0.43 | |
First diagnosis of anxiety or depression after diagnosis of heart disease | |||||
Depression† | 2.20 (1.28 to 3.79) | 0.005 | 2.34 (1.34 to 4.10) | 0.003 | |
Anxiety‡ | 1.61 (0.75 to 3.48) | 0.220 | 1.62 (0.73 to 3.59) | 0.23 | |
Tricyclic antidepressants¶ | 1.83 (1.00 to 3.37) | 0.05 | 1.82 (0.97 to 3.41) | 0.06 | |
Selective serotonin reuptake inhibitors** | 4.01 (1.41 to 11.44) | 0.009 | 4.68 (1.61 to 13.60) | 0.005 |
Model adjusted for smoking status, hypertension, diabetes, and depression score.
Relative to subjects without depression. ‡Relative to subjects without anxiety. §Relative to a baseline of no depression. ¶Relative to subjects who had not had tricyclic antidepressants. **Relative to subjects who had not had selective serotonin reuptake inhibitors.