Table 2.
hTERT Gene Expression in the Subset of Thyroid Nodules with Preoperative Suspicious FNA Diagnosis
| |
Malignant (n = 19) |
Benign (n = 31) |
||||||
|---|---|---|---|---|---|---|---|---|
| Final histology | PTC (n = 4) | FVPTC (n = 9) | FC (n = 5) | HC (n = 1) | FA (n = 14) | AN (n = 4) | HA (n = 8) | LcT (n = 1) |
| hTERT positive (n = 38) | 4 | 9 | 3 | 1 | 14 | 4 | 2 | 1 |
| hTERT full-length >0.59a (n = 11) | 4 | 1 | 3 | 1 | 1 | 0 | 1 | 0 |
a
An hTERT full-length expression cut point of 0.59 corresponded to a specificity of 0.90 and a sensitivity of 0.53.
hTERT, human telomerase reverse transcriptase; AN, adenomatoid nodule; FA, follicular adenoma; FC, follicular carcinoma; FNA, fine needle aspiration; FVPTC, follicular variant of papillary thyroid carcinoma; HA, Hürthle cell adenoma; HC, Hürthle cell carcinoma; LcT, lymphocytic thyroiditis nodule; PTC, papillary thyroid carcinoma.