TABLE 2.
Relative risk (95% CIs) of incident CHD by tertiles of Lp-PLA2 activity among 1,517 male and female diabetic subjects from the HPFS and NHS
| Tertiles of Lp-PLA2 |
P for trend | |||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| Nonfatal MI and fatal CHD | 32 | 42 | 63 | |
| Age adjusted | 1.0 | 1.25 (0.79–1.99) | 1.93 (1.25–2.97) | 0.001 |
| Multivariate adjusted* | 1.0 | 1.22 (0.75–1.99) | 1.74 (1.10–2.76) | 0.009 |
| Multivariate adjusted + LDL | 1.0 | 1.23 (0.75–2.01) | 1.75 (1.05–2.92) | 0.001 |
| CABG/PTCA | 49 | 58 | 80 | |
| Age adjusted | 1.0 | 1.13 (0.77–1.65) | 1.61 (1.12–2.30) | 0.009 |
| Multivariate adjusted* | 1.0 | 1.11 (0.75–1.63) | 1.50 (1.02–2.22) | 0.040 |
| Multivariate adjusted + LDL | 1.0 | 0.94 (0.63–1.41) | 1.12 (0.74–1.70) | 0.571 |
| Total CHD | 81 | 100 | 143 | |
| Age adjusted | 1.0 | 1.18 (0.88–1.58) | 1.76 (1.34–2.32) | <0.001 |
| Multivariate adjusted* | 1.0 | 1.15 (0.85–1.55) | 1.62 (1.21–2.17) | <0.001 |
| Multivariate adjusted + LDL | 1.0 | 1.05 (0.77–1.43) | 1.39 (1.01–1.90) | 0.034 |
Results were pooled between men and women using inverse variance weights. n = 1,517.
*Multivariate relative risks adjusted for age, fasting status, smoking, alcohol intake, physical activity, duration of diabetes, aspirin use, cholesterol-lowering medication use, family history of MI, history of hypertension, BMI, HDL, A1C, C-reactive protein, intercellular adhesion molecule, insulin use, waist circumference, estimated glomerular filtration rate, and hormone replacement therapy use (women only).