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. 1965 Jul;54(1):75–81. doi: 10.1073/pnas.54.1.75

Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis.

E M Wise Jr, J T Park
PMCID: PMC285799  PMID: 5216369

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON J. S., MATSUHASHI M., HASKIN M. A., STROMINGER J. L. LIPID-PHOSPHOACETYLMURAMYL-PENTAPEPTIDE AND LIPID-PHOSPHODISACCHARIDE-PENTAPEPTIDE: PRESUMED MEMBRANE TRANSPORT INTERMEDIATES IN CELL WALL SYNTHESIS. Proc Natl Acad Sci U S A. 1965 Apr;53:881–889. doi: 10.1073/pnas.53.4.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CHATTERJEE A. N., PARK J. T. BIOSYNTHESIS OF CELL WALL MUCOPEPTIDE BY A PARTICULATE FRACTION FROM STAPHYLOCOCCUS AUREUS. Proc Natl Acad Sci U S A. 1964 Jan;51:9–16. doi: 10.1073/pnas.51.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. COLLINS J. F., RICHMOND M. H. A structural similarity between N-acetylmuramic acid and penicillin as a basis for antibiotic action. Nature. 1962 Jul 14;195:142–143. doi: 10.1038/195142a0. [DOI] [PubMed] [Google Scholar]
  4. GHUYSEN J. M., STROMINGER J. L. STRUCTURE OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN. I. PREPARATION OF FRAGMENTS BY ENZYMATIC HYDROLYSIS. Biochemistry. 1963 Sep-Oct;2:1110–1119. doi: 10.1021/bi00905a035. [DOI] [PubMed] [Google Scholar]
  5. Hancock R., Fitz-James P. C. Some differences in the action of penicillin, bacitracin, and vancomycin on Bacillus megaterium. J Bacteriol. 1964 May;87(5):1044–1050. doi: 10.1128/jb.87.5.1044-1050.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JORDAN D. C. Effect of vancomycin on the synthesis of the cell wall mucopeptide of Staphylococcus aureus. Biochem Biophys Res Commun. 1961 Nov 20;6:167–170. doi: 10.1016/0006-291x(61)90122-x. [DOI] [PubMed] [Google Scholar]
  7. LARK C., LARK K. G. The effects of D-amino acids on Alcaligenes fecalis. Can J Microbiol. 1959 Aug;5:369–379. doi: 10.1139/m59-046. [DOI] [PubMed] [Google Scholar]
  8. Lederberg J. BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN. Proc Natl Acad Sci U S A. 1956 Sep;42(9):574–577. doi: 10.1073/pnas.42.9.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MANDELSTAM J., ROGERS H. J. The incorporation of amino acids into the cell-wall mucopeptide of staphylococci and the effect of antibiotics on the process. Biochem J. 1959 Aug;72:654–662. doi: 10.1042/bj0720654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MARTIN H. H. COMPOSITION OF THE MUCOPOLYMER IN CELL WALLS OF THE UNSTABLE AND STABLE L-FORM OF PROTEUS MIRABILIS. J Gen Microbiol. 1964 Sep;36:441–450. doi: 10.1099/00221287-36-3-441. [DOI] [PubMed] [Google Scholar]
  11. MITCHELL P., MOYLE J. Autolytic release and osmotic properties of protoplasts from Staphylococcus aureus. J Gen Microbiol. 1957 Feb;16(1):184–194. doi: 10.1099/00221287-16-1-184. [DOI] [PubMed] [Google Scholar]
  12. Meadow P. M., Anderson J. S., Strominger J. L. Enzymatic polymerization of UDP-acetylmuramyl.L-ala.D-glu.L-lys.D-ala.D-ala and UDP-acetylglucosamine by a particulate enzyme from Staphylococcus aureus and its inhibition by antibiotics. Biochem Biophys Res Commun. 1964;14:382–387. doi: 10.1016/s0006-291x(64)80014-0. [DOI] [PubMed] [Google Scholar]
  13. NEUHAUS F. C., LYNCH J. L. THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE. Biochemistry. 1964 Apr;3:471–480. doi: 10.1021/bi00892a001. [DOI] [PubMed] [Google Scholar]
  14. PARK J. T., HANCOCK R. A fractionation procedure for studies of the synthesis of cell-wall mucopeptide and of other polymers in cells of Staphylococcus aureus. J Gen Microbiol. 1960 Feb;22:249–258. doi: 10.1099/00221287-22-1-249. [DOI] [PubMed] [Google Scholar]
  15. PARK J. T., STROMINGER J. L. Mode of action of penicillin. Science. 1957 Jan 18;125(3238):99–101. doi: 10.1126/science.125.3238.99. [DOI] [PubMed] [Google Scholar]
  16. REYNOLDS P. E. Studies on the mode of action of vancomycin. Biochim Biophys Acta. 1961 Sep 16;52:403–405. doi: 10.1016/0006-3002(61)90698-9. [DOI] [PubMed] [Google Scholar]
  17. ROGERS H. J., JELJASZEWICZ J. Inhibition of the biosynthesis of cell-wall mucopeptides by the penicillins. A study of penicillin-sensitive and penicillin-resistant strains of Staphylococcus aureus. Biochem J. 1961 Dec;81:576–584. doi: 10.1042/bj0810576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SALTON M. R. Studies of the bacterial cell wall. VIII. Reaction of walls with hydrazine and with fluorodinitrobenzene. Biochim Biophys Acta. 1961 Sep 16;52:329–342. doi: 10.1016/0006-3002(61)90682-5. [DOI] [PubMed] [Google Scholar]
  19. SHOCKMAN G. D., LAMPEN J. O. Inhibition by antibiotics of the growth of bacterial and yeast protoplasts. J Bacteriol. 1962 Sep;84:508–512. doi: 10.1128/jb.84.3.508-512.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WALLAS C. H., STROMINGER J. L. Ristocetins, inhibitors of cell wall synthesis in Staphylococcus aureus. J Biol Chem. 1963 Jul;238:2264–2266. [PubMed] [Google Scholar]
  21. WEIDEL W., FRANK H., LEUTGEB W. Autolytic enzymes as a source of error in the preparation and study of gram-negative cell walls. J Gen Microbiol. 1963 Jan;30:127–130. doi: 10.1099/00221287-30-1-127. [DOI] [PubMed] [Google Scholar]
  22. WEIDEL W., PELZER H. BAGSHAPED MACROMOLECULES--A NEW OUTLOOK ON BACTERIAL CELL WALLS. Adv Enzymol Relat Areas Mol Biol. 1964;26:193–232. doi: 10.1002/9780470122716.ch5. [DOI] [PubMed] [Google Scholar]

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