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. 1969 Jan;62(1):155–162. doi: 10.1073/pnas.62.1.155

CHROMOSOMAL RECEPTOR FOR A VITAMIN D METABOLITE*

Mark R Haussler 1, Anthony W Norman 1
PMCID: PMC285968  PMID: 5253652

Abstract

Evidence has been presented for the existence of an acidic protein(s) or protein portion of a more complex molecule which has a high affinity for binding noncovalently a biologically active metabolite of vitamin D. This molecule could be solubilized from the residual chromatin via treatment with either 0.3 M KCl or high pH and has been purified 167-fold over the crude mucosa homogenate. Characterization of the still crude receptor fraction showed that it contains significant amounts of RNA and that it may exist in multiple forms, i.e., a 50,000-70,000 and a >200,000 molecular weight species. The binding capacity of the receptor fraction for the metabolite is saturated after administration of a physiological dose of the parent vitamin D.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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