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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 May;66(1):99–103. doi: 10.1073/pnas.66.1.99

Studies of Lp-Lipoprotein as a Quantitative Genetic Trait*

Nancy R Harvie 1,, Jane S Schultz 1,
PMCID: PMC286093  PMID: 4991520

Abstract

Sera from 11 individuals which were classified as Lp(a-) by direct gel diffusion and by absorption tests showed the presence of Lp(a) lipoprotein when the sera were concentrated 120-fold. This Lp(a) antigen was demonstrated by gel diffusion to be indistinguishable from Lp-lipoprotein isolated from known Lp(a+) sera. The Lp(a) preparations from sera classified Lp(a-) also showed electrophoretic mobility in immunoelectrophoresis and schlieren diagrams in ultracentrifugal analyses similar to Lp-lipoprotein from Lp(a+) sera. The proposal is made that observed individual variations in tests for the Lp-lipoprotein reflect a quantitative genetic trait and that it is likely that different individuals produce Lp-lipoprotein in widely varying amounts. The consistency of this proposal with certain previous observations on the Lp system is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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