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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Pain. 2009 Nov 28;148(1):107–113. doi: 10.1016/j.pain.2009.10.026

Fig. 4.

Fig. 4

Comparison of durations of intrathecal UFP-112- and morphine-induced antihyperalgesia in 46 °C water. The antihyperalgesic effect of the agonist, either morphine (100 nmol) or UFP-112 (10 nmol), was determined by using a single dosing procedure. The agonist was given intrathecally at different time points before administration of capsaicin (0.1 mg/tail). Each data point was determined 15 min after capsaicin administration and represents mean ± SEM (n = 6). Symbols represent effects with different dosing conditions for the same monkeys. The asterisk represents a significant difference between morphine-treated condition and the vehicle condition (*p < 0.05). The symbol # represents a significant difference between UFP-112-treated condition and the vehicle condition (*p < 0.05).