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. 1969 Sep;64(1):81–86. doi: 10.1073/pnas.64.1.81

FOOT-AND-MOUTH DISEASE VIRUS INHIBITION INDUCED IN MICE BY SYNTHETIC DOUBLE-STRANDED RNA (POLYRIBOINOSINIC AND POLYRIBOCYTIDYLIC ACIDS)*

J Y Richmond 1,2, L D Hamilton 1,2
PMCID: PMC286129  PMID: 4312754

Abstract

Synthetic 2-stranded RNA—a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)—induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of polynucleotide complex. Survival and serum interferon titers were directly related.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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