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. 1969 Sep;64(1):168–170. doi: 10.1073/pnas.64.1.168

ORGANIC ANION-BINDING PROTEIN IN RAT LIVER: DRUG INDUCTION AND ITS PHYSIOLOGIC CONSEQUENCE*

Humberto Reyes 1,†, A Jonathan Levi 1,‡, Zenaida Gatmaitan 1, Irwin M Arias 1
PMCID: PMC286142  PMID: 5262999

Abstract

The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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