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. 1969 Sep;64(1):184–189. doi: 10.1073/pnas.64.1.184

INDUCTION OF MELANIN SYNTHESIS IN ALBINO MOUSE SKIN BY DNA FROM PIGMENTED MICE*

Elena Ottolenghi-Nightingale 1
PMCID: PMC286145  PMID: 5263001

Abstract

Skin cells from albino mouse embryos have been shown to synthesize melanin after exposure to a nucleoprotein fraction of cells from pigmented mice. Although transformed clones were not found in any of 37 control experiments, at least 15 transformations took place in 10 of a series of 49 experiments using undegraded DNA. The active component in the transforming material appears to be DNA because DNase-treated preparations did not induce melanin synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ayad S. R., Fox M. DNA uptake by a mutant strain of lymphoma cells. Nature. 1968 Oct 5;220(5162):35–38. doi: 10.1038/220035a0. [DOI] [PubMed] [Google Scholar]
  2. BEARN J. G., KIRBY K. S. Failure of deoxyribonucleic acid to produce pigment changes in the albino rat. Exp Cell Res. 1959 Jun;17(3):547–549. doi: 10.1016/0014-4827(59)90083-7. [DOI] [PubMed] [Google Scholar]
  3. Fox M., Fox B. W., Ayad S. R. Evidence for genetic expression of integrated DNA in lymphoma cells. Nature. 1969 Jun 14;222(5198):1086–1087. doi: 10.1038/2221086a0. [DOI] [PubMed] [Google Scholar]
  4. Glick J. L., Salim A. P. DNA-induced pigment production in a hamster cell line. J Cell Biol. 1967 Apr;33(1):209–212. doi: 10.1083/jcb.33.1.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hill M. The uptake of deoxyribonucleic acid released from damaged cells in tissue cultures. Exp Cell Res. 1967 Mar;45(3):533–549. doi: 10.1016/0014-4827(67)90158-9. [DOI] [PubMed] [Google Scholar]
  6. Hotchkiss R. D. Portents for a genetic engineering. J Hered. 1965 Sep-Oct;56(5):197–202. doi: 10.1093/oxfordjournals.jhered.a107414. [DOI] [PubMed] [Google Scholar]
  7. KAY E. R. Incorporation of deoxyribonucleic acid by mammalian cells in vitro. Nature. 1961 Jul 22;191:387–388. doi: 10.1038/191387a0. [DOI] [PubMed] [Google Scholar]
  8. Ledoux L., Charles P. Uptake of exogenous DNA by mouse embryos. Exp Cell Res. 1967 Feb;45(2):498–501. doi: 10.1016/0014-4827(67)90200-5. [DOI] [PubMed] [Google Scholar]
  9. Ledoux L. Uptake of DNA by living cells. Prog Nucleic Acid Res Mol Biol. 1965;4:231–267. doi: 10.1016/s0079-6603(08)60790-4. [DOI] [PubMed] [Google Scholar]
  10. SZYBALSKA E. H., SZYBALSKI W. Genetics of human cess line. IV. DNA-mediated heritable transformation of a biochemical trait. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2026–2034. doi: 10.1073/pnas.48.12.2026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schlager G., Dickie M. M. Spontaneous mutations and mutation rates in the house mouse. Genetics. 1967 Oct;57(2):319–330. doi: 10.1093/genetics/57.2.319. [DOI] [PMC free article] [PubMed] [Google Scholar]

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