Abstract
This paper describes the synthesis and biological activity of [5-L-asparagine-α,β,β-d3]-deamino-oxytocin. The model peptide S-benzyl-β-mercaptopropionyl-L- asparaginyl-α,β,β-d3-glycinamide was also prepared to observe the effect of the conditions of peptide synthesis on the deuterium content. It was found that normal synthetic procedures could be used without a significant loss in the deuterium content.
The [5-L-asparagine-α,β,β-d3]-deamino-oxytocin had, within experimental error, the same avian vasodepressor and oxytocic activities as deamino-oxytocin itself.
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Selected References
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