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. 1969 Sep;64(1):275–282. doi: 10.1073/pnas.64.1.275

THE PROCESS OF INFECTION WITH BACTERIOPHAGE ϕX174, XXX. REPLICATION OF DOUBLE-STRANDED ϕX DNA*

Rolf Knippers 1,†, J Millar Whalley 1, Robert L Sinsheimer 1
PMCID: PMC286158  PMID: 5263011

Abstract

Intermediates involved in the replication of double-stranded ϕX174 RF DNA have been identified and partially characterized. Analysis of pulselabeled RF DNA suggests that the synthesis of progeny RF molecules involves, in part, the addition of nucleotides to linear complementary strands on a circular parental strand as template, so as to produce intermediate DNA strands of greater than viral length. Electron microscopy reveals DNA rings with “tails” and “double rings,” which could be the intermediate structures. A model is postulated for the replication process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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