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. 1969 Sep;64(1):290–295. doi: 10.1073/pnas.64.1.290

RELEASE OF TRAPPED MARKER FROM LIPOSOMES BY THE ACTION OF PURIFIED COMPLEMENT COMPONENTS

J A Haxby 1,2,*, O Götze 1,2,†, H J Müller-Eberhard 1,2,†, S C Kinsky 1,2,*
PMCID: PMC286160  PMID: 5263014

Abstract

Liposomes containing trapped glucose marker were prepared from the chloroform-soluble fraction of sheep erythrocyte membranes. These liposomes release glucose when incubated with rabbit anti-sheep erythrocyte serum and a source of complement. Experiments with purified human complement components show that loss of marker is absolutely dependent on the presence of components 2 and 8. An absolute requirement for component 9 cannot be demonstrated, although it stimulates glucose release from the liposomes. These results establish a parallelism between the response of biological membranes and liposomal membranes to antibody and complement.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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