Abstract
The present studies indicate that T4 infection induces an alteration in host ribosomes which restricts the translation of host and other T4-unrelated template RNAs but permits normal translation of T4 RNA. A heat-labile factor has been isolated from T4-infected cell ribosomes which, when combined with normal cell ribosomes, confers upon the latter the property of selective T4 template RNA translation.
Full text
PDF






Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Daniel V., Sarid S., Littauer U. Z. Coding by T4 phage DNA of soluble RNA containing pseudouridylic acid. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1403–1409. doi: 10.1073/pnas.60.4.1403. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ghosh H. P., Söll D., Khorana H. G. Studies on polynucleotides. LXVII. Initiation of protein synthesis in vitro as studied by using ribopolynucleotides with repeating nucleotide sequences as messengers. J Mol Biol. 1967 Apr 28;25(2):275–298. doi: 10.1016/0022-2836(67)90142-8. [DOI] [PubMed] [Google Scholar]
- Hattman S., Hofschneider P. H. Interference of bacteriophage T4 in the reproduction of RNA-phage M12. J Mol Biol. 1967 Oct 14;29(1):173–190. doi: 10.1016/0022-2836(67)90189-1. [DOI] [PubMed] [Google Scholar]
- Hsu W. T., Foft J. W., Weiss S. B. Effect of bacteriophage infection on the sulfur-labeling of sRNA. Proc Natl Acad Sci U S A. 1967 Nov;58(5):2028–2035. doi: 10.1073/pnas.58.5.2028. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Levy H. B., Carter W. A. Molecular basis of the action of interferon. J Mol Biol. 1968 Feb 14;31(3):561–577. doi: 10.1016/0022-2836(68)90428-2. [DOI] [PubMed] [Google Scholar]
- MATTHAEI J. H., NIRENBERG M. W. Characteristics and stabilization of DNAase-sensitive protein synthesis in E. coli extracts. Proc Natl Acad Sci U S A. 1961 Oct 15;47:1580–1588. doi: 10.1073/pnas.47.10.1580. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marcus P. I., Salb J. M. Molecular basis of interferon action: inhibition of viral RNA translation. Virology. 1966 Nov;30(3):502–516. doi: 10.1016/0042-6822(66)90126-7. [DOI] [PubMed] [Google Scholar]
- Sedat J. W., Kelly R. B., Sinsheimer R. L. Fractionation of nucleic acid on benzoylated-naphthoylated DEAE cellulose. J Mol Biol. 1967 Jun 28;26(3):537–540. doi: 10.1016/0022-2836(67)90321-x. [DOI] [PubMed] [Google Scholar]
- Stanley W. M., Jr, Salas M., Wahba A. J., Ochoa S. Translation of the genetic message: factors involved in the initiation of protein synthesis. Proc Natl Acad Sci U S A. 1966 Jul;56(1):290–295. doi: 10.1073/pnas.56.1.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weiss S. B., Hsu W. T., Foft J. W., Scherberg N. H. Transfer RNA coded by the T4 bacteriophage genome. Proc Natl Acad Sci U S A. 1968 Sep;61(1):114–121. doi: 10.1073/pnas.61.1.114. [DOI] [PMC free article] [PubMed] [Google Scholar]