Abstract
Natural-abundance 13C nuclear magnetic resonance spectra of ten common nucleotides in neutral, aqueous solutions have been determined and interpreted. The spectra of two of these substances were also determined in acidic solutions, and several of the carbon chemical shifts were found to depend markedly on pH. Within the limited range of concentrations employed, there were observed no carbon chemical-shift changes which could be ascribed to base-stacking or base-pairing phenomena.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chan S. I., Nelson J. H. Proton magnetic resonance studies of ribose dinucleoside monophoshates in aqueous solution. I. The nature of the base-stacking interaction in adenylyl 3'--5')adenosine. J Am Chem Soc. 1969 Jan 1;91(1):168–183. doi: 10.1021/ja01029a033. [DOI] [PubMed] [Google Scholar]
- Jones A. J., Winkley M. W., Grant D. M., Robins R. K. Carbon-13 nuclear magnetic resonance: naturally occurring nucleosides. Proc Natl Acad Sci U S A. 1970 Jan;65(1):27–30. doi: 10.1073/pnas.65.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATSON J. D., CRICK F. H. Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature. 1953 Apr 25;171(4356):737–738. doi: 10.1038/171737a0. [DOI] [PubMed] [Google Scholar]
- Weigert F. J., Jautelat M., Roberts J. D. Natural-abundance C nuclear magnetic resonance spectra of medium-molecular-weight organic compounds. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1152–1155. doi: 10.1073/pnas.60.4.1152. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weigert F. J., Roberts J. D. Nuclear magnetic resonance spectroscopy. Benzene-13C. J Am Chem Soc. 1967 Jun 7;89(12):2967–2969. doi: 10.1021/ja00988a029. [DOI] [PubMed] [Google Scholar]