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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Jan;65(1):58–62. doi: 10.1073/pnas.65.1.58

Phase Difference in the Induction of Tyrosine Hydroxylase in Cell Body and Nerve Terminals of Sympathetic Neurones

Hans Thoenen 1,*, Robert A Mueller 1,†, Julius Axelrod 1
PMCID: PMC286190  PMID: 4189989

Abstract

The induction of tyrosine hydroxylase in the nerve terminals of the rat heart by reserpine lags behind that in the stellate ganglion by two to three days. Cycloheximide given three days after reserpine blocks the further rise of the enzyme in the nerve terminals. The increase in tyrosine hydroxylase activity of the lumbar ganglion is as marked as that in the stellate ganglion. The increase of enzyme activity in the sciatic nerve after reserpine administration resembles that found in the heart nerve terminals. Determination of enzyme activity in segments of sciatic nerves indicates a two-day lag and then a proximal-distal transport of enzyme, but the apparent rate is not sufficient to account for the increase in enzyme in the nerve terminals. These findings are compatible with the local synthesis of induced tyrosine hydroxylase in the nerve terminals rather than the peripheral movement of the completed enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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