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. 1970 Jan;65(1):104–109. doi: 10.1073/pnas.65.1.104

Mechanism of Action of 2-Mercapto-1(β-4-pyridethyl)benzimidazole: A Reversible Inhibitor of Interferon Activity

Robert M Friedman 1,*, Ira Pastan 1,†
PMCID: PMC286197  PMID: 4313191

Abstract

2-mercapto-1(β-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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