Table 4.

Evaluation of maximum non-haematological toxicity per patient based on questionnaire data and physician toxicity ratings according to modified common toxicity criteria of National Cancer Institute (grade 1-2=mild to moderate, grade 3-4=severe or life threatening events)

Variable	Grade 0			Grade 1-2			Grade 3-4
	Glucose	Lipid		Glucose	Lipid		Glucose	Lipid
Bilirubin	14	15		4	6		5	4
Aspartate transaminase	11	19		12	6		0	0*
Alanine transaminase	10	18		10	5		3	2
Creatinine	12	10		11	13		0	2
Proteinuria	17	16		5	8		0	0
Haematuria	7	12		15	12		0	0
BUN concentration	8	11		12	13		3	1
Hypokalaemia	13	15		10	10		0	0
Nausea	1	6		16	11		3	4
Vomiting	5	9		12	12		4	4
Diarrhoea	5	10		13	8		3	6
Anorexia	5	5		6	9		6	7
Headache	7	13		11	9		2	0
Dysuria	16	21		3	0		0	1
Urge	14	17		5	4		0	1
Renal (other)	20	20		1	0		0	3
Renal failure	22	21		0	0		1	3
Weight gain	20	20		2	4		1	1
Weight loss	19	21		4	3		0	0
Oedema	18	11		3	8		0	3**
Dyspnoea	13	10		3	2		4	11
Cough	11	9		9	13		1	1
Lung (other)	19	14		0	3		1	5*
Arrhythmia	19	18		2	3		1	3
Hypertension	16	20		4	2		2	3
Hypotension	20	23		0	1		2	1
Vertigo	13	16		6	5		1	1
Skin	17	17		3	5		1	3
Fever (no infection)	5	7		14	17		3	1
Chills	4	8		18	17		0	0
Myalgia	11	14		9	7		0	0
Sweating	5	3		13	18		0	0
Discomfort	3	0		8	12		10	10

BUN=blood urea nitrogen.  

^*P<0.05 two sided χ² test, Mantel-Haenszel test.  

^**P<0.01 two sided χ² test, Mantel-Haenszel test.