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. 1989 Jan;86(2):458–461. doi: 10.1073/pnas.86.2.458

A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).

G P Schwartz 1, G T Burke 1, P G Katsoyannis 1
PMCID: PMC286489  PMID: 2643113

Abstract

An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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